Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1996-02-16
1999-09-21
Ulm, John
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 15, 435 691, 4352523, 43525411, 435325, 530350, 530351, C12Q 100
Patent
active
059552905
ABSTRACT:
The present invention provides for a stable, biologically active CNTF/receptor complex, and hybrids or mutants thereof. The invention is also based in part on the discovery that the CNTF/receptor complex promotes differentiation through a signal transduction pathway on target cells that do not express the CNTF receptor. The invention further provides for a specific CNTFR mutant that promotes signal transduction without binding CNTF. The invention also provides for a CNTF/receptor blocking mutant, a mutant possessing a high binding affinity to CNTF, but possessing no signal transducing function. The present invention also identifies receptor components shared by the IL-6, CNTF, LIF and OSM signal transduction pathways, and the assay systems based on the use of such components.
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Ip et al., Cell, vol. 69, p. 1121, 1992.
Stahl et al., Journal of Biol. Chem., vol. 268, p. 7628, 1993.
Velazquez et al., Cell, vol. 70, p. 313, 1992.
Wilks et al., Mol. Cell. Biol., vol. 11, p. 2057, 1991.
Witthuchor et al., Cell., vol. 74, p. 227, 1993.
Ihle James N.
Stahl Neil
Yancopoulos George D.
Kempler Gail M.
Regeneron Pharmaceuticals Inc.
St. Jude Children's Research Hospital
Teng Sally P.
Ulm John
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