Assay systems for detecting cell-free T cell antigen receptor re

Details Assay systems for detecting cell-free T cell antigen receptor re Assay systems for detecting cell-free T cell antigen receptor re

1985-12-03

1989-07-04

Warden, Robert J.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 7, 436501, 436503, 436504, 436506, 436518, 436548, 436511, 436512, 436813, 436827, G01N 3353

Patent

active

048450260

ABSTRACT:
Methods are provided for detecting and determining the amount in a sample of an antigenic determinant from an antigen receptor derived and released from a T cell or NK cell. Methods are also provided for detecting and determining the amount in a sample of an antigenic determinant from a complex of at least a portion of an antigen receptor derived from and released from a T cell or NK cell and a protein complex. These methods form the bases for methods of diagnosing and monitoring in a subject a disease characterized by the presence or an amount different from a normal subject of one of these antigenic determinants in a body fluid. A soluble antigen receptor or complex thereof derived from a T cell or a NK cell but free of such T cell or NK cell is also provided.

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