Chemistry: analytical and immunological testing – Biospecific ligand binding assay – Utilizing isolate of tissue or organ as binding agent
Patent
1980-12-24
1984-02-07
Hunt, Brooks H.
Chemistry: analytical and immunological testing
Biospecific ligand binding assay
Utilizing isolate of tissue or organ as binding agent
424 11, 436501, 436503, 436815, 436816, 422 61, G01N 3316, A61K 4300, G01T 100
Patent
active
044304358
ABSTRACT:
The accuracy of assays for monitoring concentrations of basic drugs in biological fluids containing .alpha..sub.1 -acid glycoproteins, such as blood (serum or plasma), is improved by the addition of certain organic phosphate compounds to minimize the "protein effect." Kits containing the elements of the invention are also disclosed.
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Borga, Olof, Clin. Pharmacol. Ther., vol. 22 (5 Part 1), pp. 539-544 (1977).
Patzke James V.
Rosenberg Burton J.
Brown Donald
Burroughs Wellcome Co.
Hunt Brooks H.
Moskowitz M.
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