Assay system

Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Means for analyzing liquid or solid sample

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422 8207, 422 8208, 422 8205, 436546, 436547, 436527, 436538, 436805, 435808, 356246, G01N 2100

Patent

active

053727835

ABSTRACT:
A system for assaying a fluid sample, typically employing a fluorescent tag, the system comprising a lens capable of focussing both excitation and fluorescent radiation, a fluid-flow conducting conduit being provided in the lens extending transversely of the optical axis of and through the focal region of the latter. One or more mechanical screens are disposed adjacent the focal region in the conduit to arrest passage of beads as a function of bead diameter. The beads, precoated with at least a moiety of a ligand/conjugate complex, e.g. a specific-binding ligand, are preferably substantially transparent to both the excitation and fluorescent radiation.

REFERENCES:
patent: 1716321 (1927-05-01), Pearson
patent: 2798718 (1951-10-01), Gross
patent: 3002092 (1961-09-01), Cary
patent: 3025142 (1962-03-01), Williams
patent: 3492396 (1970-01-01), Dalton et al.
patent: 3600063 (1971-08-01), Bowen
patent: 4059685 (1977-11-01), Johnson
patent: 4173392 (1979-11-01), Ekinaka et al.
patent: 4268171 (1981-05-01), Sternberg
patent: 4348107 (1982-09-01), Leif
patent: 4425438 (1984-01-01), Bauman et al.
patent: 4505260 (1985-03-01), Metzger
patent: 4585623 (1986-04-01), Chandler
patent: 4652533 (1987-03-01), Jolley
patent: 4678268 (1987-07-01), Russo et al.
patent: 4713347 (1987-12-01), Mitchell et al.
patent: 4714345 (1987-12-01), Schaader
patent: 4775515 (1988-10-01), Cottingham
patent: 4780423 (1988-10-01), Bluestein
patent: 4912051 (1990-03-01), Zaromb
Freytag et al., "Affinity-Column-Mediated Immunoenzymometric Assays: Influence of Affinity-Column Ligand and Valency of Anitbody-Enzyme Conjugates", Clin. Chem., vol. 30, No. 9, 1494-1498, 1984.
Freytag et al., "A Highly Sensitive Affinity-Column-Mediated Immunometeric Assay, as Exemplified by Digoxin", Clin. Chem., vol. 30, No. 3, 417-420, 1984.
O'Shannessy et al., "Determination of Rate of Equilibrium Binding Constants for Macromolecular Interactions Using Surface Plasmon Resonance: Use of Nonlinear Least Squares Analysis Methods", Anal. Biochem., vol. 212, 457-468, 1993.
Ralf W. Glaser, "Antigen-Antibody Binding and Mass Transport by Convection and Diffusion to a Surface: A Two-Dimensional Computer Model of Binding and Dissociation Kinetics", Anal. Biochem., vol. 213, 152-161, 1993.
Warren J. Smith, "Modern Optical Engineering. The Design of Optical Systems", McGraw-Hill Inc. (pubs) .COPYRGT.1966.
Hudson, "Infrared Systems Engineering", Wiley-Interscience, 1969.
M. E. Jolley et al., "Particle Concentration Fluorescence Immunoassay (PCFIA); A New Rapid Immunoassay Technique with High Sensitivity," Journal of Immunological Methods, 67 (1984) 21-35.
A. L. Plant et al., "Liposome Enhanced Flow Injection Immunoanalysis," Biotechnology, vol. 6, Mar. 1988, 266-269.

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