Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Means for analyzing liquid or solid sample
Patent
1994-06-24
2000-09-19
Tran, Hien
Chemical apparatus and process disinfecting, deodorizing, preser
Analyzer, structured indicator, or manipulative laboratory...
Means for analyzing liquid or solid sample
422 8205, 422 8207, 422 8208, 356246, 435808, 436805, G01N 2100
Patent
active
061207349
ABSTRACT:
A system for assaying a fluid sample, typically employing a fluorescent tag, the system comprising a lens capable of focussing both excitation and fluorescent radiation, a fluid-flow conducting conduit being provided in the lens extending transversely of the optical axis of and through the focal region of the latter. One or more mechanical screens are disposed adjacent to the focal region in the conduit to arrest passage of beads as a function of bead diameter. The beads, precoated with at least a moiety of a ligand/conjugate complex, e.g. a specific-binding ligand, are preferably substantially transparent to both the excitation and fluorescent radiation.
REFERENCES:
patent: 1716321 (1929-06-01), Pearson
patent: 2798718 (1957-07-01), Gross
patent: 3002092 (1961-09-01), Cary
patent: 3025142 (1962-03-01), Williams
patent: 3492396 (1970-01-01), Dalton et al.
patent: 3600063 (1971-08-01), Bowen
patent: 4059685 (1977-11-01), Johnson
patent: 4153675 (1979-05-01), Kleinerman
patent: 4173392 (1979-11-01), Ekinaka et al.
patent: 4268171 (1981-05-01), Sternberg
patent: 4348107 (1982-09-01), Leif
patent: 4425438 (1984-01-01), Bauman et al.
patent: 4469787 (1984-09-01), Woods et al.
patent: 4505260 (1985-03-01), Metzger
patent: 4582809 (1986-04-01), Block et al.
patent: 4585623 (1986-04-01), Chandler
patent: 4652533 (1987-03-01), Jolley
patent: 4678268 (1987-07-01), Russo et al.
patent: 4713347 (1987-12-01), Mitchell et al.
patent: 4714345 (1987-12-01), Schrader
patent: 4775515 (1988-10-01), Cottingham
patent: 4780423 (1988-10-01), Bluestein et al.
patent: 4912051 (1990-03-01), Zaromb
patent: 4963498 (1990-10-01), Hillman et al.
patent: 5120643 (1992-06-01), Ching et al.
patent: 5183740 (1993-02-01), Ligler et al.
Freytag et al., "Affinity-Column-Mediated Immunoenzymometric Assays: Influence of Affinity-Column Ligand and Valency of Antibody-Enzyme Conjugates", Clin. Chem., V. 30, No. 9, 1494-1498, 1984.
Freytag et al., "A Highly Sensitive Affinity-Column-Mediated Immunometric Assay, as Exemplified by Digoxin", Clin. Chem., V. 30, No. 3, 417-420, 1984.
O'Shannessy et al., "Determination of Rate of Equilibrium Binding Constants for Macromolecular Interactions Using Surface Plasmon Resonance: Use of Nonlinear Least Squares Analysis Methods", Anal. Biochem, V. 212, 457-468, 1993.
Ralf W. Glaser, "Antigen-Antibody Binding and Mass Transport by Convection and Diffusion to a Surface: A Two-Dimensional Computer Model of Binding and Dissociation Kinetics", Anal. Biochem., V. 213, 152-161, 1993.
Warren J. Smith, "Modern Optical Engineering. The Design of Optical Systems", McGraw-Hill, Inc. (pubs) .COPYRGT.1966.
Hudson, "Infrared Systems Engineering", Wiley-Interscience, 1969.
M. E. Jolley et al., "Particle Concentration Fluorescence Immunoassay (PCFIA); A New Rapid Immunoassay Technique with High Sensitivity", Journal of Immunological Methods, vol. 67, 21-35, 1984.
A. L. Planet et al., "Liposome Enhanced Flow Injection Immunoanalysis", Biotechnology, vol. 6, 266-269, Mar. 1988.
Gunaratna et al., "Noncompetitive flow injection immunoassay for a hapten, .alpha.-(Difluoromethyl)ornithine", Anal. Chem, 1993, 65, pp. 1152-1157.
G. Gubitz et al., "Flow-injection immunassays", Analytica Chimica Acta, 283, 1993, pp. 421-428.
Pollema et al., "Flow injection renewable surface immunoassay: a new approach to immunoanalysis with fluorescence detection", Anal. Chem., 1994, p. 1825-1831.
Friguet et al., "Measurements of the true affinity constant in solution of antigen-antibody complexes by enzyme-linked immunosorbent assay", Jour. of Immun. Methods, 77, p. 305-319, 1985.
Pollema et al., "Sequential injection immunoassay utilizing immunomagnetic beads", Anal. Chem. 64, p. 1356-1361, 1992.
Jarrell Brenda H.
Sapidyne, Inc.
Tran Hien
LandOfFree
Assay system does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Assay system, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Assay system will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1069170