Assay reagents and devices

Details Assay reagents and devices Assay reagents and devices

1997-09-23

2000-10-17

Minnifield, Nita

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is organic

436531, 436534, 436514, 436810, 435970, 435805, 422 56, G01N 33546, G01N 33545, G01N 33549, G01N 3353

Patent

active

061330485

ABSTRACT:
A reagent useful in immunoassays, comprising a direct particulate level co-sensitized with a specific binding agent having specificity for an analyte or analyte analog and with a non-specific protein which can participate in a control reaction with another specific binding agent which does not bind to the first specific binding agent nor participate in the formation of a complex by means of which detection of the analyte or analyte analog is accomplished. Preferably the first specific binding agent is an antibody raised in a first species and the non-specific protein is an immunoglobulin from another species. Optionally, the reagent additionally comprises a second population of the direct particulate label sensitized solely with the non-specific protein.

REFERENCES:
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patent: 4680274 (1987-07-01), Sakai et al.
patent: 4812414 (1989-03-01), Warren, III et al.
patent: 5356782 (1994-10-01), Moorman et al.
patent: 5679581 (1997-10-01), Miyazaki et al.
Ed Harlow and David Lane. Antibodies: A Laboratory Manual. 1988. pp. 608 and 632.

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