Chemistry: analytical and immunological testing – Peptide – protein or amino acid – Amino acid or sequencing procedure
Reexamination Certificate
2002-05-22
2009-12-15
Chin, Christopher L (Department: 1641)
Chemistry: analytical and immunological testing
Peptide, protein or amino acid
Amino acid or sequencing procedure
C435S007100, C530S840000
Reexamination Certificate
active
07632684
ABSTRACT:
In an in vitro diagnostic test for osteoarthritis or rheumatoid arthritis, the amount or presence in a sample of anisomerised or optically inverted protein fragment is measured which derives from perlecan, bigylcan, decorin, fibrillin-1 or protocadherin or which is a specific sequence from aggrecan, type II collagen, COMP or CILP.
REFERENCES:
patent: 6107047 (2000-08-01), Fledelius et al.
patent: 6849594 (2005-02-01), Chen et al.
patent: WO 01/05422 (2001-01-01), None
patent: WO 96/30765 (1996-10-01), None
patent: WO 98/39653 (1998-09-01), None
Vilim et al. “Characterization of Monoclonal Antibodies Recognizing Different Fragments of Cartilage Oligomeric Matrix Protein in Human Body Fluids” Archives of Biochemistry and Biophysics 341, 8-16, 1997.
van den Oetelaar et al. “Analysis of aspartic acid racemization; Evaluation of a chiral capillary gas chromatographic and a diastereomeric high-performance liquid chromatographic method” J Chromatogr. Feb. 13, 1987;388(2):441-7.
Wolfe, S.L., Molecular and Cellular Biology, 1993, pp. 790-793.
Kuby et al. Immunology, W.H. Freeman and Company (1992), p. 125.
Bendayan, M. J. Histochem. Cytochem. 1995; 43:881-886.
Bost et al. Immunol. Invest. 1988; 17:577-586.
Arikawa-Hirasawa, et al. “Perlecan is essential for cartilage and cephalic development” Nature Genetics, Nature America, New York, U.S., vol. 23, No. 3, Nov. 1999, pp. 354-358, XP001034683.
Costell, et al., “Perlecan Maintains the Integrity of Cartilage and Some Basement Membranes” The Journal of Cell Biology, Rockefeller University Press, U.S., vol. 147, No. 5, Nov. 29, 1999, pp. 1109-1122, XP002906976.
International Search Report dated Feb. 1, 2004 issued in corresponding application No. PCT/EP02/05612.
Adams, “The Thrombospondin Type 1 Repeat (TSR) Superfamily: Diverse Proteins With Related Roles in Neuronal Development”, Dev Dyn. (2000) 218: 280-299.
Clark et al., “Serum Cartilage Oligomeric Matrix Protein Reflects Osteoarthritis Presence and Severity”, the Johnston County Osteoarthritis Project, Arthritis Rheum (1999) 42: 2356-2364.
Clarke, “Propensity for Spontaneous Succinimide Formation from Aspartyl and Asparaginyl Residues in Cellular Proteins”, Int. J. Peptide Protein Res. (1987) 30:808-821.
Costell et al., “Perlecan Maintains the Integrity of Cartilage and Some Basement Membranes”, J Cell Biol. (1999) 147:1109-1122.
Dodge et al., “Osteoarthritis and Cartilage”, Osteoarthritis Cartilage (1998) 6, 435-440.
Eyre, “The Collagens of Articular Cartilage”, Semin. Arthritis Rheum. 21 (suppl. 2): 2-11, 1991.
Flannerly et al., “Identification of a Stromelysin Cleavage with the Interglobular Domain of Human Aggrecan”, J Biol. Chem. (1992) 267: 1008-1014.
Fledeluis et al., “Characterization of Urinary Degradation Products Derived from Type 1 Collagen. Identification of a β-Isomerized Asp-Gly sequence within the C-telopeptide (α1) region”, J Biol. Chem. (1997) 275:9755-9763.
Ganu at al., “Inhibition of Interleukin-1α-Induced Cartilage Oligomeric Matrix Protein Degradation in Bovine Articular Cartilage by matrix Metalloproteinase Inhibitors”, Arthritis Rheum (1998) 41:2143-2151.
Geiger et al., “De-amidation, Isomerization, and Racemization at Asparaginyl and Aspartyl Residues in Peptides”, J Biol. Chem. (1987) 262(2):785-794.
Hardingham et al., “Proteoglycans: Many Forms and Many Functions” FASEB J (1992)6:861-870.
Hardingham et al., “The Specific Interation of Lyaluronic acid with cartilage proteoglycans”, Biochim Biophys Acta (1972) 279:401-405.
“Chondrex: New Marker of Joint Disease”, Clin. Chem (1998) 44:509-516, Harvey et al.
Heinegard et al., “A Method for the Quantification of Cartilage Proteoglycan Structures Liberated to the Synovial Fluid During Developing Degenerative Joint Disease”, Scand J Clin Lab Invest (1985) 45:421-427.
Heinegard et al., “Noncollagenous Proteins; Glycoproteins and Related Proteins” Dynamics of Bone and Cartilage Metabolism, Academic Press, NY (1999) pp. 59-69.
Hermanson, “Bioconjugate Techniques” Academic Press (1996) San Diego, USA, pp. 194-196.
Inerot et al, “Articular-Cartilage Proteoglycans in Aging and Osteoarthritis”, Glycoconjugates vol. IV, Academic Press, NU (1982) pp. 335-355.
Johansen et al., “A New Biochemical Marker for Joint Injury. Analysis of YKL-40 in Serum and Synovial Fluid”, Br. J. Rheumatol (1993) 32:949-955.
Johansen et al., “Serum YKL-40 Levels in Healthy Children and Adults. Comparison with Serum and Synovial Fluid Levels of YKL-40 in Patients with Osteoarthrltis or Trauma of the Knee Joint”, Br. J. Rheumatol. (1996) 35:553-559.
Kudson et al., “Cartilage Proteoglycans” Semin. Cell Dev. Biol. (2001) 12:69-78.
Lorenzo et al., “A Novel Cartilage Protein (CILP) Present in the Mid-zone of Human Articular Cartilage Increases with Age” J. Biol. Chem. (1998a) 273(36):23463-23468.
Lorenzo et al., “Cloning and Deduced Amino Acid Sequence of a Novel Cartilage Protein (CILP) Identifies a Proform Including a Nucleotide Pyrophosphohydrolase” J. Biol. Chem, 273(36):23469-23475, 1998.
Niedhart et al., “Small Fragments of Cartilage Oligomeric Matrix Protein in Synovial Fluid and Serum as Markers for Cartilage Degradation” Br. J. Rheumatol. 36:1151-1160, 1997.
Poole et al., “Biological Markers in Rheumatoid Arthritis” Sem. Arthr. Rheum. (1994) 23:17-31.
Poole et al, Methods for Evaluating Mechanisms of Cartilage Breakdown Cartilage Breakdown: Basic and Clinical Aspects, Marcel Dekker, New York, (1993) 225-260.
Radkiewicz et al., “Accelerated Racemization of Aspartic Acid and Asparagine Residues via Succinimide Intermediates: An ab Initio Theoretical Exploration of Mechanism” J. Am. Chem. Soc. (1996) 118:9148-9155.
Rafferty et al., “Pharmacokinetic Evaluation of Superactive Analogues of Growth Hormone-Releasing Factor (1-29)-Amide” Peptides (1988) 9(1):207-9.
Rosenberg et al, “Cartilage Oligomeric Metrix Protein Shows High Affinity Zinc-dependent Interaction with Triple Helical Collagen” J. Biol. Chem (1998) 273:20397-20403.
Saxne et al., “Cartilage Oligomeric Matrix Protein: A Novel Marker of Cartilage Turnover Detectable in Synovial Fluid and Blood” Br. J. Rheumatol. (1992) 31: 583-591.
Saxne et al., “Concise Communications—Serum Concentrations of Two Cartilage Matrix Proteins Reflecting Different Aspects of Cartilage Turnover in Relapsing Polychondritis” Arthritis Rheum (1995) 38:294-296.
Van Der Rest et al., “Collagen Family of Proteins” FASEB J (1991) 5:2814-2823.
Van Regenmortel et al., “D-peptides as Immunogens and Diagnostic Reagents” Current Opinion in Biotechnology (1998) 9:377-382.
Vingsbo-Lundberg et al., “Increased Serum Levels of Cartilage Oligomeric Matrix Protein in Chronic Erosive Arthritis in Rats”Arthritis Rheum (1998) 41:544-550.
Wollheim, et al., “Predictors of Joint Damage in Rheumatoid Arthritis” APMIS (1996) 104:81-93.
Sakai, et al., “Fillbrillin, A New 350-kD Glycoprotein, Is a Component of Extracellular Microfibrils” J Cell Biol (Dec. 1986) 103 (6 Pt 1): 2499-509.
Keene et al., “Fibrillin-1 in Human Cartilage: Developmental Expression and Formation of Special Banded Fibers” J. Histochem Cytochem (Aug. 1997) 45(8):1069-82.
Zhang et al., “Developmental Expression of Fibrillin Genes Suggests Heterogeneity of Extracellular Microfibrils” J Cell Biol (May 1995) 129(4)1165-76.
Didonato et al., “Selective Deamidation of Ribonuclease A” J Biol Chem (1993) 268:4745-4751.
Stevenson at al., “Comparison of Separation and Detection Techniques for Human Growth Hormone Releasing Factor (hGRF) and the Products Derived from Deamidation”
Christgau Stephan
Cloos Paul A. C.
Henriksen Dennis B.
Butler, Esq. Gregory B.
Chin Christopher L
Edwards Angell Palmer & & Dodge LLP
Foster Christine
Nordic Bioscience Diagnostics A/S
LandOfFree
Assay of isomerised and/or optically inverted proteins and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Assay of isomerised and/or optically inverted proteins and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Assay of isomerised and/or optically inverted proteins and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4093522