Assay of immune complexes

Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...

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23230B, 252408, G01N 3316

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active

041419650

ABSTRACT:
A method for the estimation of an immune complex and analysis of a constituent thereof, comprising a latex particle agglutination test, in which a sample comprising immune complex is incubated with coated latex particles and IgM antibodies, the latex particles coated with said complex constituent and the IgM antibodies being low affinity non-human antibodies to said complex consituent. Also a kit for use in the method of the invention comprising low affinity non-human IgM antibodies to the constituent of complex undergoing analysis, and latex particles coated with said constituent.

REFERENCES:
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patent: 3899298 (1975-08-01), Szezesniak
patent: 4062935 (1977-12-01), Masson
R. J. Levinsky et al., Abstract presented at Renal Association Meeting, Oct. 1976.
R. J. Levinsky et al., Jour. Clin. and Exper. Immunology, Oct. 21, 1977.
Lurhuma et al., "Clinical and Experimental Immunology" (1976) 25, pp. 212-226.
Eisenberg, "Immunochemistry," 1976, vol. 13, pp. 355-359.
Sobel et al., The Journal of Experimental Medicine, vol. 142, pp. 139-150 (1975).
Little et al., Methods in Immunology and Immunochemistry, vol. 1, pp. 128-133 (1967).
E. Engvall et al., Jour. of Immunology, 109 (1), pp. 129-135 (1972).

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