Assay of gentamicin in blood

Details Assay of gentamicin in blood Assay of gentamicin in blood

1974-03-18

1976-04-06

Monacell, A. Louis

Textiles: fiber preparation

G01N 3316, G01T 116

Patent

active

039487296

ABSTRACT:
The ability of gentamicin to inhibit urease synthesis by a gentamicin susceptible strain of an adaptive urease producing microorganism is employed to provide an assay for the concentration of gentamicin present in the blood of a patient being treated with gentamicin. The gentamicin concentration in the liquid portion of blood is determined by comparing the amount of C.sup.14 O.sub.2 produced by a gentamicin susceptible strain of an adaptive urease producing microorganism from a culture medium containing an aliquot of blood test sample and a measured amount of C.sup.14 urea with the C.sup.14 O.sub.2 produced by that microorganism from controls using known concentrations of gentamicin in blood samples.

REFERENCES:
patent: 3676679 (1972-07-01), Waters
noone et al., Lancet, 2(7714), July 3, 1971, pp. 16-19.
Bersaques, Liquid Scintillation Counting, Vol. 3, "A Micromethod for Urease," 303-306, (1973).
McDonald et al., Enzymologia, Vol. 42, (1972), pp. 1-9.
Chemical Abstracts, 78:93000y.

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