Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1995-05-19
1999-08-17
Scheiner, Toni R.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
53038885, 53038825, 5303893, 435 723, 435326, C07K 1618, C07K 1630, G01N 33574
Patent
active
059395338
ABSTRACT:
According to the method of the invention, immunoassays are applied to measure free PSA as well as a proteinase inhibitor complex. Free PSA and PSA complex are according to the invention measured by a non-competitive immunoassay employing at least two different monoclonal antibodies. The invention is further characterized by that the PSA proteinase inhibitor complex of interest is formed either with .alpha..sub.1 -antichymotrypsin, .alpha..sub.1 -protease inhibitor (API) or .alpha..sub.2 -macroglobulin. Moreover, the invention is characterized by that free PSA, the PSA-proteinase inhibitor complex and their ratio are applied in the diagnosis of patients with prostate cancer.
REFERENCES:
patent: 4446122 (1984-05-01), Chu et al.
Seibatsu Busturi-gaku, 31, pp. 371-378 (1987).
Rinsho Byori, Supp. 68, pp. 50-56 (1986).
Rinsho Byori, 32(7): pp. 781-785 (1984).
Rinsho Kensa, 29(1): pp. 87-90 (1985).
Nichi-hinyo-kaisha, 80(3): pp. 349-352 ) 1989).
Hinyoki Geka, 8(1): pp. 5-9 (1995).
Nihon Rensho, 53, pp. 753-756 (1995).
Studies on Determination of .gamma.-Seminoprotein (.gamma.-SM) In Sera by Enzyme Immunoassay, Rinsyo Kensa 28(13); pp. 1755-1758 (1984).
Maier, U. et al. (1990). "Gamma-seminoprotein--a New Tumour Marker in Prostatic Cancer?", Brit. J. Urol., vol. 65, pp. 509-512 (1990).
Alfthan, H. et al. (1988). "Time Resolved Fluoroimmunoassays," Am. Biotech. Lab. vol. 6, pp. 8-13.
Stenman, U. et al. (1990). "Time Resolved Immunofluorometric Assay of Prostate-Specific Antigen," J. Nucl. Med. Allied Sci., vol. 34, Suppl. to No. 3, pp. 249-251.
0219-870 EPO The General Hospital Corp. Apr. 29, 1987.
Stenman, U. Et al. (1991). "A Complex between Prostate-specific Antigen and .alpha..sub.1- antichymotrypsin is the major form of Prostate-Specific Angigen in serum of patients with Prostatic Cancer: Assay of the Complex Improved Clinical Sensitivity for Cancer," Cancer Res. vol. 51, pp. 222-226.
Wang, M.C. et al. (1981). "Prostate Antigen: A New Potential Marker for Prostatic Cancer," The Prostate, vol. 2, pp. 89-96.
Siddal, J.K. et al. (1986). "Measurements of Serum .gamma.-Seminoprotein and Prostate Specific Antigen Evaluated for Monitoring Carcinoma of the Prostate," Clinical Chemistry, vol. 32, No. 11, pp. 2040-2043.
Demura, T. et al. (1993). "Measurement of Prostate Specific Antigen and .gamma.-Seminoprotein Ratio: A New Means of Distinguishing Benign Prostatic Hyperplasia and Prostate Cancer," J. Urology, vol. 150, pp. 1740-1745.
Lilja, H. et al. (1988). "Three Predominant Proteins Secreted by the Human Prostate Gland," The Prostate, vol. 12, pp. 29-38.
Schaller, J. et al. (1987). "Isolation, characterization and amino acid sequence of .gamma.-seminoprotein, a glycoprotein from human seminal plasma," Eur. J. Biochem. vol. 170, pp. 111-120.
Wang, M.C. et al. (1982). "Prostate Antigen of Human Cancer Patients," Methods in Cancer Res., vol. XIX, Chap.IV, pp. 179-197.
Arai, Y. et al. (1989). "Multiple Marker Evaluation in Prostatic Cancer Using Prostatic Specific Antigen, Gamma-Seminoprotein and Prostatic Acid Phosphatase," Urol. Int., vol. 44, pp. 135-140.
Tsukamoto, T. et al. (1988). "Clinical Study of Tumor Marker in Prostatic Carcinoma," Acta. Urol. Jpn. 34:987-995.
Chandra, T. et al. (1983). "Sequence Homology Between Human .alpha.1-Antichymotrypsin, .alpha.1-Antitrypsin, and Antithrombin III," Biochemistry, vol. 22, No. 22, pp. 5055-5060.
"Antibodies, A Laboratory Manual," edited by Harlow and Lane, Cold Spring Harbor Laboratory (1988), pp. 567-569.
Hara, M. et al. (1989). Two prostate-specific antigens, .gamma.-seminoprotein and .beta.-microseminoprotein, J. Lab. Clin. Med., vol. 113, No. 5, pp. 541-548.
Kawakami, K. et al. (1993). Rinsho Kagaku 22, pp. 42-48, English translation.
Papsidero, L. et al. (1980). "A Prostate Antigen in Sera of Prostatic Cancer Patients," Cancer Res., vol. 40, pp, 2428-2432.
Kuriyama, M. et al. (1986). "Clinical Evaluation of .gamma.-Seminoprotein in Prostate Cancer," The Prostate, 8:301-311.
U.S. Patent 4,446,122, issued May 1, 1984 to Chu et al.
Christensson, A. et al. (1990). "Enzymatic activity of prostate-specific antigen and its reactions with extracellular serine proteinase inhibitors," Eur. J. Biochem., vol. 194, pp. 755-763.
Watt, K. et al. (1986). "Human prostate-specific antigen: Structural and functional similarity with serine proteases," Proc.Natl.Acad.Sci. 83:3166-3170.
Akiyama, K. et al. (1987). The chymotrypsin-like activity of human prostate-specific antigen, .gamma.-seminoprotein, FEBS Letts., vol. 225, No. 1.2, pp. 168-172.
Travis J. et al. (1978). "Human .alpha.-1-Antichymotrypsin: Purification and Properties," Biochem. 17:5647-5651.
Lundwall, A. et al. (1987). "Molecular cloning of human prostate specific antigen cDNA," FEBS Letts., vol. 214, No. 2, pp. 317-322.
Laskowski, M. et al. (1980). "Protein Inhibitors of Proteinases," Ann. Rev. Biochem., vol. 49, pp. 593-626.
Nakamura, R.M. (1994). "Current and Future Directions Regarding Quality Assurance and Standardization of Prostate Specific Antigen Immunoassays," Cancer, vol. 74, No. 6, pp. 1655-1659.
Chichibu, K. et al. (1996). Abstract 1546, The Journal of Urology, AUA 91st Ann. Mtg., vol. 155, No. 5, Suppl. 697A.
Burr, W. A. et al. (1979). "The Ratio of Thyroxine to Thyroxine-Binding Globulin in the Assessment of Thyroid Function,." Clin. Endocrinol. 11:333-342.
Schmidt, F.W. et al.. part 1, Diagnostic of Liver Diseases (title translated), pp. E384-E389, 1984.
Kuntz, E., Diagnosis of Liver Diseases (translated), pp. 52-57, 1980.
Abrahamsson, P. et al. (1988). "Immunohistochemical Distribution of the Three Predominant Secretory Proteins in the Parenchyma of Hyperplastic and Neoplastic Prostate Glands," The Prostate, vol. 12, pp. 39-46.
U.S. Patent 4,933,275, issued Jun. 12, 1990 to Wands et al.
Demura, T. et al. (1996). "The Proportion of Free to Total Prostate Specific Antigen," Am. Cancer Soc., vol. 77, No. 6, pp. 1137-1143.
Okabe, T. et al. (1985). "Clinical Evaluation of Prostate-Specific Antigens," J. Jpn. Urol. Soc., vol. 76, No. 2, pp. 165-173.
New York Academy of Sciences; N.Y. Annals, vol. 417 (1983) Chu et al., "Circulating Antibody to Prostate Antigen in Patients with Prostatic Cancer," (pp. 383-389).
Patent Abstracts of Japan, vol. 11, No. 233, P600, Abstract of Japanese Patent 62-46263, publ. Feb. 28, 1987; Chugai Pharmaceut. Co. Ltd.
Watt et al. (1986). Proc. Natl. Acad. Sci. USA 83:3166.
Lilja, H. (1985). J. Clin. Invest. 76:1899.
Stenman, U.-H. (1990). "Some Examples of the Effect of Immunoassay Design on Clinicty Utility", Clinical Chemistry 36(6):1244-1245.
Lilja Hans
Stenman Ulf-H.ang.kan
LandOfFree
Assay of free and complexed prostate-specific antigen (PSA) does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Assay of free and complexed prostate-specific antigen (PSA), we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Assay of free and complexed prostate-specific antigen (PSA) will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-315821