Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1990-08-07
1992-09-01
Nucker, Christine
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
435 23, 435 24, 530412, 530416, C12Q 137, C12N 952
Patent
active
051438399
ABSTRACT:
The invention relates to highly purified aminopeptidases derived from Streptomycetes which are heat stable. There is further provided assay for the detection and quantitative determination of Neutral Endopeptidase 24.11 and Neutral Proteinase 24.4. A specific aminopeptidase is one derived from Streptomyces griseus, which is a calcium activated metalloprotein.
REFERENCES:
patent: 4146432 (1979-03-01), Hirohara
Vosbeck et al. (1973) The Proteolytic Enzymes of the K-1 ---J. Biol. Chem. 248: 6029-6034.
Vitale et al. (1986) Streptomyces-rimosus extracellular Proteases III, Isolation and Characterization of Leucine Aminopeptidase, Appl-Microbiol. Biotechnical: 23(6): 449-455.
Vosbeck et al., The Proteolytic Enzymes of the K-1 Strain of Streptomyces griseus Obtained from a Commercial Preparation (Pronase), Specificity and Immobilization of Aminopeptidase, J. Biol. Chem., vol. 250, No. 10 pp. 3981-3987, 19075.
Vosbeck et al., Proteolytic Enzymes of the K-1 Strain of Streptomyces griseus Obtained from a Commercial Preparation (Pronase), Effect of pH, Metal Ions and Amino Acids on Aminopeptidase Activity, J. Biol. Chem., vol. 253, No. 1, pp. 257-260, 1978.
Blumberg Shmaryahu
Indig Fred E.
Meir Daniela B.
Spungin Anya
Nucker Christine
Preston David R.
Ramot Ltd.
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