Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1994-05-23
1997-06-03
Chin, Christopher L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
422 55, 422 58, 4352871, 4352872, 4352881, 435810, 435967, 436172, 436514, 436518, 436524, 436528, 436531, 436536, 436538, 436541, 436805, 436810, 436824, 73 6143, 73 6151, 73 6172, 73444, G01N 33543, G01N 33558
Patent
active
056353626
ABSTRACT:
A patient's health may be diagnosed by centrifuging blood samples in a transparent tube, which tube contains one or more bodies or groups of bodies such as floats, inserts, liposomes, or plastic beads of different densities. Each density-defined body carries analyte-capture binding materials such as antigens or antibodies, which are specific to an epitope, or other specific high affinity binding site on a target analyte which target analyte may be in the blood or other sample being tested; and the level of which analyte is indicative of the patient's health. At least one labeled binding material which is also specific to an epitope, or other specific high affinity binding site on the target analyte is added to the sample so as to form labeled binding material/analyte/body complexes in the sample. Upon centrifugation, the complexes will settle out in different areas in the tube according to the respective density of the body or bodies; and the degree of label emission of the complex layers can enable qualitative and/or quantitative analyses of the sample to be made. Unbound labeled binding materials will be separated from the complexed layers by the washing action of ascending or descending components of the sample during the centrifugation step. Unbound labeled binding material will thus not interfere with the analysis.
REFERENCES:
patent: 4027660 (1977-06-01), Wardlaw et al.
patent: 4077396 (1978-03-01), Wardlaw et al.
patent: 4082085 (1978-04-01), Wardlaw et al.
patent: 4137755 (1979-02-01), Wardlaw et al.
patent: 4159896 (1979-07-01), Levine et al.
patent: 4197287 (1980-04-01), Piasio et al.
patent: 4225575 (1980-09-01), Piasio et al.
patent: 4567754 (1986-02-01), Wardlaw et al.
patent: 4717660 (1988-01-01), Schulte
patent: 4774965 (1988-10-01), Rodriguez et al.
patent: 4843869 (1989-07-01), Levine et al.
patent: 4875364 (1989-10-01), Levine et al.
patent: 4940668 (1990-07-01), Wardlaw et al.
patent: 4952054 (1990-08-01), Levine et al.
patent: 5234816 (1993-08-01), Terstappen
patent: 5252460 (1993-10-01), Fiedler et al.
patent: 5342790 (1994-08-01), Levine et al.
patent: 5403714 (1995-04-01), Levine et al.
patent: 5460979 (1995-10-01), Levine et al.
Levine Robert A.
Malick Adrien P.
Ozinskas Alvydas J.
Rodriguez Rodolfo R.
Wardlaw Stephen C.
Becton Dickinson and Co.
Chin Christopher L.
Jones William W.
LandOfFree
Assay of blood or other biologic samples for target analytes does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Assay of blood or other biologic samples for target analytes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Assay of blood or other biologic samples for target analytes will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-390600