Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1998-08-25
2000-01-18
Prouty, Rebecca E.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 29, 435196, 43525421, 4352523, C12Q 168
Patent
active
060156775
ABSTRACT:
The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca.sup.2+ /calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
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Beavo Joseph A.
Bentley Kelley J.
Charbonneau Harry
Sonnenburg William K.
Hutson Richard
Prouty Rebecca E.
The Board of Regents of the University of Washington
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