Assay methods for suppressor of fused modulation of hedgehog...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S007900, C435S008000

Reexamination Certificate

active

07579161

ABSTRACT:
The present invention is directed to novel polypeptides having homology to a polypeptide suppressor of theDrosophila melanogasterfused protein and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

REFERENCES:
patent: 6448020 (2002-09-01), Toftgard et al.
patent: 2252965 (2000-06-01), None
patent: 99/32517 (1999-07-01), None
Kogerman et al., 1999 (Sep.), Nature Cell Biology 1:312-319.
Accession No. AA223637, EST Mar. 12, 1998.
U.S. Appl. No. 60/076,072, filed Feb. 26, 1998, de Sauvage et al.
Akimaru et al., “Drosophila CBP is a Co-Activator of Cubitus Interruptus in Hedgehog Signalling.”Nature. 386:735-738 (Apr. 17, 1997).
Albarosa et al., “Deletion Mapping of Gliomas Suggests the Presence of Two Small Regions for Candidate Tumor-Suppressor Genes in a 17-cM Interval on Chromosome 10q.”Am. J. Hum. Genet.58:1260-1267 (1996).
Alcedo et al., “The Drosophila Smoothened Gene Encodes a Seven-Pass Membrane Protein, A Putative Receptor for the Hedgehog Signal.”Cell. 86:221-232 (1996).
Alexandre et al., “Transcriptional Activation of Hedgehog Target Genes in Drosophila is Mediated Directly by the Cubitus Interrruptus Protein, A Member of the GLI Family of Zinc Finger DNA-Binding Proteins.”Genes&Development. 10 (16) :2003-2013 (Aug. 15, 1996).
Altschul and Gish, “Local Alignment Statistics”Methods in Enzymology266:460-480 (1996).
Apelqvist et al., “Sonic Hedghog Directs Specialised Mesoderm Differentiation in the Intestine and Pancreas.”Current Biology. 7 (10) :801-804 (Oct. 1, 1997).
Bellusci et al., “Involvement of Sonic Hedgehog (Shh) in Mouse Embryonic Lung Growth and Morphogenesis.”Development. 124 (1) :53-63 (Jan. 1997).
Bitgood et al., “Sertoli Cell Signaling by Desert Hedgehog Regulates the Male Germline.”Current Biology. 6 (3) :298-304 (1996).
Bowie et al., “Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Subtitutions”Science247:1306-1310 (1990).
Busson et al., “Genetic Analysis of Viable and Lethal Fused Mutants of Drosophila Melanogaster.”Roux's Archives of Developmental Biology197:221-230 (1988).
Carpenter et al., “Characterization of Two Patched Receptors for the Vertebrate Hedgehog Protein Family.”Proc. Natl. Acad. Sci. USA95 (23) :13630-13634 (1998).
Chen and Struhl., “Dual Roles for Patched in Sequestering and Transducing Hedgehog.”Cell. 87 (3) :553-563 (Nov. 1, 1996).
Chiang et al., “Cyclopia and Defective Axial Patterning in Mice Lacking Sonic Hedgehog Gene Function.”Nature. 383 (6599) :407-413 (Oct. 3, 1996).
Chidambaram et al., “Mutations in the Human Homologue of the Drosophila Patched Gene in Caucasian and African-Amerian Nevoid Basal Cell Carcinoma Syndrome Patients.”Cancer Research. 56 (20) :4599-4601 (Oct. 15, 1996).
Delattre et al., “The Suppressor of Fused Gene, Involved in Hedgehog Signal Transduction in Drosophila, Is Conserved in Mammals.”Dev. Genes Evol.209:294-300 (May 1999).
Dominguez et al., “Sending and Receiving the Hedgehog Signal: Control by the Drosophila Gli Protein Cubitus Interruptus.”Science. 272 (5268) :1621-1625 (Jun. 14, 1996).
Echelard et al., “Sonic Hedgehog, A Member of a Family of Putative Signaling Molecules, is Implicated in the Regulation of CNS Polarity.”Cell. 75:1417-1430 (1993).
Ericson et al., “Sonic Hedgehog Induces the Differentiation of Ventral Forebrain Neurons: A Common Signal for Ventral Patterning Within the Neural Tube.”Cell. 81 (5) :747-756 (Jun. 2, 1995).
Fan and Tessier-Lavigne., “Patterning of Mammalian Somites by Surface Ectoderm and Notochord: Evidence for Sclerotome Induction by a Hedgehog Homolog.”Cell. 79 (7) :1175-1186 (Dec. 30, 1994).
Gailani et al., “The Role of the Human Homologue of Drosophila Patched in Sporadic Basal Cell Carcinomas.”Nature Genetics. 14:78-81 (Sep. 1996).
Goodrich et al., “Altered Neural Cell Fates and Medulloblastoma in Mouse Patched Mutants.”Science. 277:1109-1113 (Aug. 1997).
Goodrich et al., “Conservation of the Hedgehog/Patched Signaling Pathway from Flies to Mice: Induction of a Mouse Patched Gene by Hedgehog.”Genes Dev.10 (3) :301-312 (1996).
Gray et al., “Loss of the Chromosomal Region 10q23-25 in Prostate Cancer.”Cancer Research. 55:4800-4803 (Nov. 1995).
Hahn et al., “Mutations ot the Human Homolog of Drosophila Patched in the Nevoid Basal Cell Carcinoma Syndrome”Cell85:841-851 (1996).
Hammerschmidt et al., “Protein Kinase A is a Common Negative Regulator of Hedgehog Signaling in the Vertebrate Embryo.”Genes&Development. 10 (6) :647-658 (Mar. 15, 1996).
Hammerschmidt et al., “The World According to Hedgehog”Trends in Genetics13 (1) :14-21 (1997).
Heng and Tsui., “Modes of DAPI Banding and Simultaneous In Situ Hybridization.”Chromosoma. 102 : 325-332 (1993).
Heng et al., “High-Resolution Mapping of Mammalian Genes by In Situ Hybridization to Free Chromatin.”Proc. Natl. Acad. Sci. USA89:9509-9513 (Oct. 1992).
Hooper and Scott., “The Drosophila Patched Gene Encodes a Putative Membrane Protein Required for Segmental Patterning.”Cell. 59:751-765 (1989).
Hynes et al., “Control of Cell Pattern in the Neural Tube by the Zinc Finger Transcription Factor and Oncogene Gli-1.”Neuron. 19 (1) :15-26 (Jul. 1997).
Hynes et al., “Induction of Midbrain Dopaminergic Neurons by Sonic Hedgehog”Neuron15:35-44 (1995).
Ingham, “Signalling by Hedgehog Family Proteins in Drosophila and Vertebrate Development.”Curr. Opin. Genet. Dev.5:492-498 (1995).
Ingham, “Transducing Hedgehog: The Story So Far.”EMBO Journal17:3505-3511 (1998).
Jiang and Struhl, “Regulation of the Hedgehog and Wingless Signalling Pathways by the F-box/WD40-repeat Protein Slimb.”Nature391:493-496 (Jan. 29, 1998).
Johnson and Scott., “New Players and Puzzles in the Hedgehog Signaling Pathway.”Curr. Opin. Genet. Dev.8:450-456 (1998).
Johnson et al., “Ectopic Expresssion of Sonic Hedgehog Alters Dorsal—Ventral Patterning of Somites.”Cell. 79:1165-1173 (1994).
Johnson et al., “Human Homolog of Patched, a Candidate Gene for the Basal Cell Nevus Syndrome”Science272:1668-1671 (1996).
Krauss et al., “A Functionally Conserved Homolog of the Drosophila Segment Polarity Gene hh is Expressed in Tissues with Polarizing Activity in Zebrafish Embryos.”Cell. 75:1431-1444 (1993).
Krishnan et al., “Mediation of Sonic Hedgehog—Induced Expression of COUP-TFII by a Protein Phosphatase.”Science. 278 (5345) :1947-1950 (Dec. 12, 1997).
Laufer et al., “Sonic Hedgehog and Fgf-4 Act Through a Signaling Cascade and Feedback Loop to Integrate Growth and Patterning of the Developing Limb Bud.”Cell. 79 (6) :993-1003 (Dec. 16, 1994).
Lee et al., “Glil is a Target of Sonic Hedgehog that Induces Ventral Neural Tube Development.”Development. 124 (13) :2537-2552 (Jul. 1997).
Li et al., “PTEN, A Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer.”Science. 275:1943-1947 (Mar. 1997).
Marigo et al., “Biochemical Evidence that Patched is the Hedgehog Receptor.”Nature. 384 (6605) : 176-179 (Nov. 14, 1996).
Mariol et al., “Molecular Cloning of Fused, a Gene Required for Normal Segmentation in the Drosophila Melanogaster Embryo.”Molecular&Cellular Biology7 :3244-3251 (Sep. 1987).
Marra et al., “Sequence Alignment with 09581

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Assay methods for suppressor of fused modulation of hedgehog... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Assay methods for suppressor of fused modulation of hedgehog..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Assay methods for suppressor of fused modulation of hedgehog... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4063647

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.