Assay methods for detecting serum proteases, particularly activa

Details Assay methods for detecting serum proteases, particularly activa Assay methods for detecting serum proteases, particularly activa

1991-07-03

1994-02-22

Griffin, Ronald W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

435 71, 436548, 436518, C12Q 137

Patent

active

052886123

ABSTRACT:
The invention describes diagnostic methods and compositions for determining the amount of protease in a body fluid sample. In particular, the invention detects proteases by a method in which both a reversible inhibitor of the protease and an irreversible inhibitor of interfering proteases during the detection step are employed to increase the sensitivity of the enzyme capture assay. The assay detects normal serum levels of activated protein C.

REFERENCES:
Geiger et al., Thrombosis and Haemostasis, 61(1), pp. 86-92, 1989.
Heeb et al., Blood, 73, pp. 446-454; 455-461, 1989.
Comp, et al., Blood, 63: 15-21 (1984).
Exner, et al., J. Lab. Clin. Med., 107: 405-411 (1986).
Gruber, et al., Blood, 73: 639-642 (1989).
Tabernero, et al., Thromb. Haemost., 63: 380-382 (1990).

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