Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2004-08-31
2011-11-22
Cook, Lisa (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007100, C436S501000, C436S518000
Reexamination Certificate
active
08062855
ABSTRACT:
The invention relates to assays in which complexes between an analyte and a binding agent specific for the analyte are detected by a reporter molecule, which is capable of binding to the binding agent when the binding agent is complexed with analyte but not when the binding agent is complexed with an analyte analogue. The invention provides a method of modifying such a binding agent in order to create a tailored site where the reporter molecule may bind to the binding agent. This provides control over the location and nature of the reporter binding site. Antibodies, including bispecific antibodies, are preferred binding agents. The invention also provides novel methods for labelling antibodies close to their antigen binding site using bi- and tri-functional reagents. Modified binding agents produced by the methods described are also provided.
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Arnold & Porter LLP
Cook Lisa
Dreger Ginger R.
Selective Antibodies Limited
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