Surgery – Truss – Pad
Patent
1984-10-31
1987-01-13
Howell, Kyle L.
Surgery
Truss
Pad
324308, A61B 504
Patent
active
046356436
ABSTRACT:
An in vivo assay for quantifying the mineral content of bone comprises placing living bone into or adjacent to the coil of a nuclear magnetic resonance (NMR) spectrometer, recording a .sup.31 P NMR spectrum while the bone is stationary, and comparing the spectrum obtained with the NMR spectrum of a reference standard containing a known concentration of a reference compound. The assay can be used to diagnose and determine the efficacy of treatment of osteodystrophy if used in conjunction with radiographic densitometry to estimate the calcium content of the bone.
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Tropp, J. et al, "Phosphorus NMR Study of Solid Amorphous Calcium Phosphate", J. Am. Chem. Soc., 1983, vol. 105, pp. 22-26.
Rothwell, W. P. et al, "High-Resolution Variable-Temperature .sup.31 P NMR of Solid Calcium Phosphates", J. Am. Chem. Soc., 102:8, 4/9/1980, pp. 2637-2643.
Herzfeld, J. et al., "Magic Angle Sample Spinning in Inhomogeneously Broadened Biological Systems", Phil. Trans. Royal Soc. London B 289, pp. 459-469, (1980).
General Electric brochure: "Chemical Shift Imaging Systems" (1983).
Phospho-Energetics, Inc. brochure "In Vivo Nuclear Magnetic Resonance- PE 250-80." (1983).
Howell Kyle L.
Jaworski Francis J.
The Medical College of Wisconsin Research Foundation Inc.
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