Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-06-05
1997-11-11
Loring, Susan A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 71, 435 72, 5303871, 5303881, 53038823, 53038824, 5303913, G01N 3353, G01N 3358, C07K 1624, C07K 1626
Patent
active
056862598
ABSTRACT:
Cleavage site blocking antibody that binds to prohormones, preferable Tumor Necrosis Factor, thereby preventing the formation of prohormone fragment(s) by proteolysis of the prohormone, and uses of the antibody including prophylactic and therapeutic methods to treat disease, and diagnostic assays for determining the amount of the prohormone and prohormone fragments present in a patients body.
REFERENCES:
patent: 4474893 (1984-10-01), Reading
patent: 4870163 (1989-09-01), Rubin et al.
Kriegler, M. et al., Cell, 53:45-53, Apr. 8, 1988.
Christa, N.V., Perspectives in Shock Research, 264:115-24, 1988.
Maggio, E.T., Enzyme-Immunoassa, pp. 171-179, CRC Press, Inc, Boca Raton, FL 1980.
Bringman, T.S. et al., Hybridana, 6(5):489-507, 1987.
Madsen, O.D. et al., Endocrinology, 113(6):2135-2144, 1983.
Fendly, Brian M. et al, Hybridoma, 6(4):359-370, 1987.
Aggarwal et al., "Human Tumor Necrosis Factor," The Journal of Biological Chemistry, 260(4):2345-2354 (Feb. 25, 1985).
Decker et al., "Cell-Associated Tumor Necrosis Factor (TNF) As A Killing Mechanism of Activated Cytotoxic Macrophages," The Journal of Immunology, 138(3):957-962 (Feb. 1, 1987).
Bringman et al., "Monoclonal Antibodies to Human Tumor Necrosis Factors Alpha and Beta: Application for Affinity Purification, Immunoassays, and as Structural Probes," Hybridoma, 6(5):489-507 (1987).
Fendly et al., "Murine Monoclonal Antibodies Defining Neutralizing Epitopes on Tumor Necrosis Factor," Hybridoma, 6(4):359-370 (1987).
Jemmerson et al., "Monoclonal antibodies block the trypsin cleavage site on human placental alkaline phosphatase," FEBS 173(2):357-359 (Aug. 1984).
Kohler, et al., "Continuous cultures of fused cells secreting antibody of predefined specificity," Nature, 256:495-499 (Aug. 7, 1975).
Kriegler et al., "A Novel Form of TNF/Cachectin Is A Cell Surface Cytotoxic Transmembrane Protein: Ramifications for the Complex Physiology of TNF," Cell, 53:45-53 (Apr. 8, 1988).
Milstein, C., et al., Immun. Today, 5(10):299-304 (1984).
Pennica et al., "Human tumor necrosis factor: precursor strcture, expression and homology to lymphotoxin," Nature, 312:724-729 (Dec. 1984).
Scuderi, P., "Suppression of Humann Leukocyte Tumor Necrosis Factor Secretion by the Serine Proteae Inhibitor p-Toluenesulfonyl-.sub.L -Arginine Methyl Ester (TAME)", The Journal of Immunology, 143(1):168-173 (Jul. 1, 1989).
Shimamoto et al., "Monoclonal antibodies against human recombinant tumor necrosis factor: Prevention of endotoxic shock," Immunology Letters, 17:311-318 (1988).
Socher et al., "Antibodies against amino acids 1-15 of tumor necrosis factor block its binding to cell-surface receptor," Proc. Natl. Acad. Sci. USA, 84:8829-8833 (Dec. 1987).
Steiner et al., "Use of a synthetic peptide antigen to generate antisera reactive with a proteolytic processing site in native human proinsulin: Demonstration of cleavage within clathrin-coated (pro)secretory vesicles," Proc. Natl. Acad. Sci. USA, 84:6184-6188 (Sep. 1987).
Tooze et al., "An Antibody Specific for an Endoproteolytic Cleavage Site Provides Evidence That Pro-opiomelanocortin Is Packaged Into Secretory Granules in AtT20 Cells before Its Cleavage," The Journal of Cell Biology, 105:155-162 (1987).
Tracy et al., "Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia," Nature, 330:662-664 (Dec. 17, 1987).
Kriegler Michael
Perez Carl
Blackburn Robert P.
Chiron Corporation
Loring Susan A.
Pochopien Donald J.
Savereide Paul B.
LandOfFree
Assay method for the detection of 26kd TNF prohormone does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Assay method for the detection of 26kd TNF prohormone, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Assay method for the detection of 26kd TNF prohormone will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1227893