Chemistry: analytical and immunological testing – Biospecific ligand binding assay – Utilizing isolate of tissue or organ as binding agent
Patent
1983-03-09
1985-05-28
Nucker, Christine M.
Chemistry: analytical and immunological testing
Biospecific ligand binding assay
Utilizing isolate of tissue or organ as binding agent
436804, 436808, 436815, G01N 3360, G01T 100
Patent
active
045201129
ABSTRACT:
A method for measuring the level of organic calcium antagonist drug in a body fluid comprises preparing a mixture of a radioactive calcium antagonist drug, a body fluid containing a calcium antagonist drug and a calcium antagonist receptor material, measuring the radioactivity of the radioactive calcium antagonist drug bound to said calcium antagonist receptor material and deriving the concentration of the calcium antagonist drug in the body fluid from a standard curve indicating the concentration of calcium antagonist drug versus inhibition of binding of said radioactive calcium antagonist drug to said receptor sites caused by the calcium antagonist drug in said body fluid. A kit for measuring the level of an organic calcium drug comprises a receptacle containing a radioactive calcium antagonist drug, a calcium antagonist receptor material and a standard amount of a nonradioactive calcium antagonist drug.
REFERENCES:
Murphy et al., Evr. J. Pharmacol 77 (1982) 201-202.
Murphy et al., Proc. Natl. Acad. Sci. USA 80 (1983) 860-864.
Gould et al., Proc. Natl. Acad. Sci. USA 79 (1982) 3656-3660.
McAllister et al., J. Pharmaceutical Sci., 65 (1976) 431-432.
Gould Robert J.
Snyder Solomon H.
Nucker Christine M.
The Johns Hopkins University
LandOfFree
Assay method for organic calcium antagonist drugs and a kit for does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Assay method for organic calcium antagonist drugs and a kit for , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Assay method for organic calcium antagonist drugs and a kit for will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-869290