Assay kit and methods for neuroleptic drugs

Details Assay kit and methods for neuroleptic drugs Assay kit and methods for neuroleptic drugs

1990-12-21

1992-04-14

Ceperley, Mary E.

Chemistry: analytical and immunological testing

Biospecific ligand binding assay

Utilizing isolate of tissue or organ as binding agent

436501, 436503, 540576, G01N 33567, C07D22316

Patent

active

051048140

ABSTRACT:
The invention describes a kit and a method useful for analyzing the plasma concentration of an active neuroleptic drug known to have D-1 receptor antagonist properties utilizing labeled [-]trans 6,7,7a,8,9,13b-hexahydro-3-chloro-2-hydroxy-N-methyl-5H-benzo[d]naphtho-[2 ,1-b]-azepine.

REFERENCES:
patent: 4760029 (1988-07-01), Barnett et al.
Iorio et al., J. Pharm. Exp. Ther., vol. 226, No. 2, pp. 462-468 (1983).
Chipkin et al., J. Pharm. Exp. Ther., vol. 247, No. 3, pp. 1093-1102 (1988).
McQuade et al., J. Pharm. Exp. Ther., vol. 257, No. 1, pp. 42-48 (1991).

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