Assay for vitamin B12 deficiency

Details Assay for vitamin B12 deficiency Assay for vitamin B12 deficiency

1986-05-22

1987-07-14

Richman, Barry S.

Chemistry: analytical and immunological testing

Heterocyclic carbon compound

Diverse hetero atoms in same or different rings

436 93, 436 96, 436177, 436178, 436505, 436811, G01N 3382

Patent

active

046802738

ABSTRACT:
An assay for Vitamin B.sub.12 deficiency by determining for a blood sample that essentially all of the Vitamin B.sub.12 is carried by a combination of TCI and TCIII and/or essentially no Vitamin B.sub.12 is carried by TCII. TCII may be conveniently separated from a combination of TCI and TCIII by precipitating TCII with silica. Vitamin B.sub.12 deficiency may be determined prior to the onset of anemia and/or nerve damage by determining a decrease in Vitamin B.sub.12 carried by TCII.

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Allen et al, J. of Bio. Chem., vol. 248, No. 10, pp. 3660-3669, 1973.
Frenkel et al, Am. J. of Clin. Path., vol. 53, No. 6, pp. 891-903, 1970.

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