Assay for tumor promoting agents

Details Assay for tumor promoting agents Assay for tumor promoting agents

1984-05-21

1986-02-11

Richman, Barry S.

Chemistry: analytical and immunological testing

Cancer

435 29, 4351721, 435948, C12N 1500, C12Q 102, C12R 191

Patent

active

045699160

ABSTRACT:
A composition is tested to determine whether it is a tumor promoter or a complete carcinogen by exposing a stable epithelial cell line to the composition for an incubation time period sufficient to induce morphological changes in the cell line. After the incubation time, the cells are observed by morphology changes induced by the composition, which changes are compared to that caused by a known tumor promoter or a known complete carcinogen.

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de Serres et al., (eds.), Chemical Mutagens, vol. 6, 1971.
Altenburg et al., Cancer Res., vol. 36, pp. 251-257, 1976.
Berwald et al., J. Natl. Cancer Inst., vol. 35, No. 4, 1965, pp. 641-657.

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