Assay for TSG101 as inhibitors of HIV production

Details Assay for TSG101 as inhibitors of HIV production Assay for TSG101 as inhibitors of HIV production

2002-05-21

2009-02-24

Campbell, Bruce (Department: 1648)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

C435S005000, C435S006120, C435S007100

Reexamination Certificate

active

07494767

ABSTRACT:
The present invention provides methods for identifying peptides in a mammalian. Tsg101 protein that binds to the PTAPP (SEQ ID NO: 3) motif or L domain of human immunodeficiency virus type I (HIV-1). Such peptides can be used to inhibit Tsg101-HIV Gag binding, and is therefore effective in reducing HIV particle production. The invention also provides the peptides identified by the method of the invention and to method of using such peptides for treating HIV infection.

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Database GSP, “Human secreted protein, SEQ ID No. 5770”, XP002331139, retrieved from EBI Database accession No. AAG01689 (Oct. 2000).
Dettenhofer et al., “Proline Residues in Human Immunodeficiency Virus Type 1 p6GagExert a Cell Type-Dependent Effect on Viral Replication and Virion Incorporation of Pol Proteins”,Journal of Virology, vol. 73, No. 6, pp. 4696-4704 (Jun. 1999).
VerPlank et al., “Tsg101, a homologue of ubiquitin-conjugating (E2) enzymes, binds the L domain in HIV type 1 Pr55Gag”,PNAS, vol. 98, No. 14, pp. 7724-7729 (Jul. 2001).
Goff et al. “Tsg101 Control of Human Immunodeficiency Virus Type 1 Gag Trafficking and Release”,Journal of Virology, vol. 77, No. 17, pp. 9173-9182 (Sep. 2003).

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