Chemistry: analytical and immunological testing – Heterocyclic carbon compound – Hetero-n
Patent
1991-05-30
1992-09-22
Cashion, Jr., Merrell C.
Chemistry: analytical and immunological testing
Heterocyclic carbon compound
Hetero-n
436903, 422 61, G01N 3300
Patent
active
051492725
ABSTRACT:
Novel reagent compositions and an assay method for the measurement of total and direct bilirubin are disclosed. The reagent compositions comprise an aqueous solution of at least one betaine selected from the group of alkyl betaine, betaine and betaine hydrate, a sulfanilamide diazonium salt, iodide ions and sulfamic acid. In the measurement of total bilirubin, alkyl betaine serves as an accelerator/solubilizer for the reaction of unconjugated bilirubin, and the alkyl betaine, betaine or betaine hydrate, together with iodide ions, minimizes or substantially eliminates interference from hemoglobin and lipemia.
REFERENCES:
patent: 4468467 (1984-08-01), Babb et al.
patent: 4563429 (1986-01-01), Doumas et al.
patent: 4665038 (1987-05-01), Sakata et al.
Dappen et al., vol. 29/1, Clinical Chemistry, 37-41 (1983).
Sasaya et al., Patent Abstracts of Japan, vol. 5, No. 95, Jun. 1981.
Bohannon Jeanne
Simmons Mark J.
White Yolanda
Wu Yih-Shiong
Amick Marilyn L.
Boehringer Mannheim Corporation
Cashion Jr. Merrell C.
Celsa B.
Kenemore Max J.
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