Assay for tissue factor in a sample

Details Assay for tissue factor in a sample Assay for tissue factor in a sample

2003-11-06

2009-10-20

Saucier, Sandra (Department: 1651)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Reexamination Certificate

active

07604932

ABSTRACT:
The invention provides assays for detecting and quantitating tissue factor and factor VIIa in simple and complex biological systems. The assays are performed by detecting and/or measuring the tissue factor cofactor activity and factor VIIa enzymatic activity using aminonapthalene-based fluorogenic substrates.

REFERENCES:
patent: 5399487 (1995-03-01), Butenas et al.
patent: 6287794 (2001-09-01), Safar et al.
patent: 7049087 (2006-05-01), Jenny et al.
Butenas et al. “Synthetic substrates for human factor Vlla and factor Vlla-tissue factor” Biochem. (1993) 32: 6531-6538.
Butenas et al. “Cooperative interaction of divalent metal ions, substrate and tissue factor with factor Vlla” Biochem. (1994) 33:3449-3456.

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