Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing
Patent
1996-10-04
2000-08-01
Kunz, Gary L.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
435325, 435 11, 435 12, 435 4, 436503, G01N 33567, C12N 506
Patent
active
060963026
ABSTRACT:
The present invention provides a method to determine the extent of neuronal degradation due to aging, a learning disability, or a neurological disorder, which includes: (a) stimulating a neuronal cell population under suitable conditions so as to induce a late-phase long term potentiation; (b) stimulating a normal neuronal cell population under suitable conditions so as to induce a late-phase long term potentiation; and (c) comparing the duration of the late-phase long term potentiation of the neuronal cell population in step (a) with that of the normal neuronal cell population of step (b) so as to determine the extent of neuronal degradation due to aging, the learning disability or the neurological disorder. The learning disability or neurological disorder may be Alzheimer's Disease, a degenerative disorder associated with learning, memory or cognitive dysfunction, cerebral senility, multi-infarct dementia and senile dementia, electric shock induced amnesia or amnesia.
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Bach Mary E.
Kandel Eric R.
Zhuo Min
Gucker Stephen
Kunz Gary L.
The Trustees of Columbia University in the City of New York
White John P.
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