Assay for the detection of paclitaxel resistant cells in...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C436S501000, C436S518000

Reexamination Certificate

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09574099

ABSTRACT:
Tubulin mutations commonly associated with resistance to paclitaxel are defined, and PCR allele-specific primers capable of detecting the mutations in DNA from tumor cells are described as well as method for treating paclitaxel-resistant cells in tumors. A simple, rapid, and cost effective means for detecting paclitaxel-resistant cells in tumor biopsies from patients receiving paclitaxel therapy is disclosed.

REFERENCES:
patent: WO 00/71752 (2000-11-01), None
Drexler et al (Leukemia and Lymphoma, 1993, 9:1-25).
Embleton et al (Immunol Ser, 1984, 23:181-207.
Hsu (in Tissue Culture Methods and Applications, Kruse and Patterson, Eds, 1973, Academic Press, NY, see abstract, p. 764).
Gonzalez-Garay, Manuel L., A B-Tubulin Leucine Cluster Involved in Microtubule Assembly and Paclitaxel Resistance. Journal of Biological Chemistry vol. 274 (34) Aug. 20, 1999. pp. 23875-23882.
Nogales, Eva, et al. Structure of the xB Tubulin dimer by electron crystallography. Nature, vol. 391, Jan. 8, 1998, pp. 199-203. (XP-002143079).
Jordan, Allan, et al Tubulin as a Target for Antiancer Drugs: Agents Which Interact with the Mitotic Spindle. 1998 pp. 259-296. (XP-000886283).
Ginnakakou, Paraskevi, et. al. Paclitaxel-resistant Human Ovarian Cancer Cells have Mutant B-Tublins that Exhibit Impaired Paclitaxel-driven Polymerization. Journal of Biological Chemistry. vol. 272 (27) Jul. 4, 1997, pp. 17118-17125. (XP-002111288).
Cabral, Fernando, et al Resistance to Antimitotic Agents as Genetic Probes of Microtubule Structure and Function. Pharmac. Ther. vol. 52, pp. 159-171, 1991. (XP-000961706).

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