Assay for the detection of epigenetic toxic (non-genotoxic) subs

Details Assay for the detection of epigenetic toxic (non-genotoxic) subs Assay for the detection of epigenetic toxic (non-genotoxic) subs

1984-11-16

1987-10-20

Marantz, Sidney

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

424 3, 435 29, 436 63, 436 64, 436519, 436813, G01N 3350, G01N 3353, G01N 33567, G01N 33574

Patent

active

047014067

ABSTRACT:
An in vitro assay procedure for the detection of non-genotoxic substances is provided which utilizes a prepared cell culture whose cytoskeleton constituents are structurally identifiable as microtubules, intermediate filaments and microfilaments. The procedure combines the test sample with the cultured cells and detects a presence of epigenetic substances by identifying structural changes in the cytoskeletal constituents in comparison to normal control cells. The assay method is rapid, accurate, reproducible, and has been demonstrated to identify toxic substances which have not been previously detected by presently known bacterial and/or mammalian cell mutagenic assay systems.

REFERENCES:
patent: 4404181 (1983-09-01), Mauthner
Parness, J. et al., Biochem. Biophys. Res. Commun., 105(3), 1082-1089 (1982).
Chemical Abstracts, I, 93: 160973t (1980).
Chemical Abstracts, II, 95: 72889f (1981).
"Cellular Systems for Toxicity Testing", G. M. Williams et al., eds., Annals of the New York Academy of Sciences, vol. 407, New York, 1983.

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