Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-03-07
1998-01-06
Myers, Carla J.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 435 9121, 435 915, 435 9151, 436 63, 436 64, 536 2431, 536 2433, 935 77, 935 78, C12Q 168, C07H 2104, C12P 1934
Patent
active
057053367
ABSTRACT:
Assay of the mRNA levels of ERCC1 and XPAC, two genes whose products are involved in DNA repair, provides a method for determining the sensitivity of tumors to treatment by platinum-based chemotherapy. Tumors that are resistant to cisplatin tend to express high levels of the mRNA for ERCC1 which includes exon VIII. In some tumor types, concurrent expression of ERCC1 and XPAC mRNAs is also an indicator of cisplatin resistance.
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Dabholkar Meenakshi
Reed Eddie
Myers Carla J.
The United States of America as represented by the Department of
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