Assay for myasthenia gravis

Details Assay for myasthenia gravis Assay for myasthenia gravis

1978-03-20

1979-07-31

Turk, Arnold

Chemistry: physical processes

Physical processes

Crystallization

23230B, 23920, 424 1, 424 15, 424 12, G01N 3316, A61K 4300

Patent

active

RE0300594

ABSTRACT:
A serum assay system for diagnosis of myasthenia gravis. The assay system includes a complex of acetylcholine receptor protein and a toxin labeled with a radioactive isotope. The complex is incubated with a serum sample from a patient. During incubation, antibodies engendered by myasthenia gravis bind to receptor sites in the complex. The resulting complex containing the antibodies is precipitated by addition of anti-immunoglobulin. Radioactivity in the resulting precipitate is measured and compared with a control.

REFERENCES:
fambrough et al., "Neuromuscular Junction in Myasthenia Gravis Decreased Acetylcholine Receptors," Science, vol. 182, Oct. 1973, pp. 293-295.
Almon et al., "Serum Globulin in Myasthenia Gravis: Inhibition of .alpha.-Bungarotoxin Binding to Acetylcholine Receptors," Science, vol. 186, No. 4158, Oct. 1974, pp. 55-57.
Skelley et al., "Radioimmunoassay," Clinical Chemistry, vol. 19, No. 2, (1973), pp. 146, and 161-163.

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