Assay for mutagenesis in bacterial cells

Details Assay for mutagenesis in bacterial cells Assay for mutagenesis in bacterial cells

1977-10-17

1981-11-10

Tanenholtz, Alvin E.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 34, 435172, C12Q 168

Patent

active

042999154

ABSTRACT:
An assay is disclosed for determining mutagenic damage caused by the administration of a known or suspected mutagen to bacterial cells such as Salmonella typhimurium. After administration of or exposure to a mutagenic agent, the bacterial cells are plated in the presence of a purine analog and resistance to purine analogs is used as the genetic marker. This bioassay system can be used by genetic toxicologists to determine the potential genetic hazards from the use of a variety of suspected or known mutagens, including newly-developed chemicals.

REFERENCES:
patent: 3071518 (1963-01-01), Sherr et al.
patent: 3298923 (1967-01-01), Banno et al.
patent: 4072574 (1978-02-01), Loeb

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