Chemistry: analytical and immunological testing – Involving immune complex formed in liquid phase
Patent
1997-09-12
1999-02-16
Housel, James C.
Chemistry: analytical and immunological testing
Involving immune complex formed in liquid phase
436546, 436800, 436808, 435975, G01N 33536, G01N 33533
Patent
active
058720146
ABSTRACT:
The invention generally features a rapid, quantitative method of diagnosing multi-drug resistance in a patient. The method involves (a) exposing cells of a biological specimen to a calcein compound, the calcein compound becoming fluorescent in the cell; and (b) measuring calcein compound accumulating in the specimen cells relative to control cells, reduced calcein accumulation in specimen cells relative to control cells indicating the presence of multi-drug resistance in the biological specimen. The method is useful for diagnosing multi-drug resistance in patients undergoing drug therapy, e.g., chemotherapeutic or antibiotic therapy.
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Hollo Zsolt
Homolya Laszlo
Sarkadi Balazs
Helfenstein Allegra J.
Housel James C.
Shaver Jennifer
Skaugset Anton E.
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