Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-10-23
2007-10-23
Gitomer, Ralph (Department: 1657)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
Reexamination Certificate
active
10739485
ABSTRACT:
There is provided an assay for identifying compounds which interact with the γ-secretase complex, in particular compounds that lower the production of Aβ42.
REFERENCES:
patent: WO 01/075435 (2001-10-01), None
patent: WO 2003/008635 (2003-01-01), None
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D. Beher et al., “InVitro Characterization of the Presenilin-Dependent Gamma-Secretase Complex Using a Novel Affinity Ligand”, Biochemistry, vol. 42, pp. 8133-8142 (2003).
A. Kornilova et al., “Differential Effects of Inhibitors on the Gamma-Secretase Complex”, The Journal of Biological Chemistry, vol. 278, No. 19, pp. 16470-16473 (2003).
A. Weihofen et al., “Targeting Presenilin-type Aspartic Protease Signal Peptide Peptidase with Gamma-Secretase Inhibitors”, The Journal of Biological Chemistry, vol. 278, No. 19, pp. 16528-16533 (2003).
I. Pinnix et al., “A Novel Gamma-Secretase Assay Based on Detection of the Putative C-terminal Fragment-Gamma of Amyloid Beta Protein Precusor”, The Journal of Biological Chemistry, vol. 276, No. 1, pp. 481-487 (2001).
Gitomer Ralph
Merck Sharp & Dohme Limited
Shen Bin
Todaro John C.
Winokur Melvin
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