Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Reexamination Certificate
2008-05-27
2008-05-27
Weber, Jon (Department: 1657)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
C435S029000
Reexamination Certificate
active
10435439
ABSTRACT:
The invention provides methods for the identification of agents that modify or mimic P protein function. Cells expressing a P protein are generally more sensitive to toxins, and changes in cell viability and/or cell death after exposure of P protein-expressing cells to an agent and a toxin is an indication that such an agent is a modifier of P protein expression. The invention also provides methods for the treatment of melanoma and other cancers.
REFERENCES:
patent: 5066489 (1991-11-01), Paradise et al.
patent: 5214028 (1993-05-01), Tomita et al.
patent: 5389611 (1995-02-01), Tomita et al.
patent: 5627033 (1997-05-01), Smith et al.
patent: 5731325 (1998-03-01), Andrulis, Jr. et al.
patent: 5789215 (1998-08-01), Berns et al.
patent: 5814618 (1998-09-01), Bujard et al.
patent: 5851984 (1998-12-01), Matthews et al.
patent: 6132740 (2000-10-01), Hu
patent: 6139854 (2000-10-01), Kawato
patent: 6291196 (2001-09-01), Vielkind et al.
patent: 6794137 (2004-09-01), Blumenberg
patent: 6861239 (2005-03-01), Blumenberg et al.
patent: 6953664 (2005-10-01), Blumenberg et al.
patent: 7105292 (2006-09-01), Blumenberg
patent: 2002/0034772 (2002-03-01), Orlow et al.
patent: 2004/0175767 (2004-09-01), Orlow et al.
patent: 2006/0188953 (2006-08-01), Orlow et al.
patent: WO-88/09810 (1988-12-01), None
patent: WO 01/01131 (2001-01-01), None
patent: WO-01/01131 (2001-04-01), None
Dooley et al. Development of an In Vitro Primary Screen for Skin Depigmentation and Antimelanoma Agents; Skin Pharmacol., vol. 7, Issue 4(1994) pp. 188-200.
Goering et al. The Enigma of Arsenic Carcinogenesis: Role of Metabolism; Toxicological Sciences, vol. 49 (1999) pp. 5-14.
Puri et al. Aberrant pH of Melanosomes in Pink-Eyed Dilution (P) Mutant Melanocytes; The Journal of Investigative Dermatology, vol. 115, No. 4 (2000) pp. 607-613.
Manga, P. et al., Inverse Correlation Between Pink Eyed Dilution Protein Expression and Induction of Melanogenesis by Bafilomycin A1. Pigment Cell Research, 2001, vol. 14, No. 5, pp. 362-367.
U.S. Appl. No. 09/827,428, filed Mar. 21, 2002, Orlow et al.
Brilliant, M H. “The Mouse P (Pink-eyed Dilution) and Human P Genes, Oculocutaneous Albinism Type 2 (OCA2), and Melanosomal PH.”Pigment Cell Research. Copenhagen, DK 143(2):86-93 (2001).
Chaudhuri et al., “apd1+, a Gene Required for Red Pigment Formation inade6Mutants ofSchizosaccharomyces prmbe, Encodes an Enzyme Required for Glutathione Biosynthesis: A Role for Glutathione and a Glutathione-Conjugate Pump”,Genetics145:75-83 (1997).
Del Marmol, Veronique et al. “Glutathione Depletion Increases Tyrosinase Activity in Human Melanoma Cells.”Journal of Investigative Dermatology, 101(6):871-874 (1993).
European Search Report for European Patent Application No. 03 731 127.1 ,ailed Jul. 13, 2007.
Gahl et al., “Melanosomal Tyrosine Transport in Normal and Pink-eyed Dilution Murine Melanocyte”,Pigment. Cell. Res, 8:229-233 (1995).
Gautier et al., “α-DNA IV; α-anomeric and β-anomeric tetrathymidylates Covalently Linked to Intercalcating Oxazolopyridocarbazole. Synthesis, physiochemical properties and poly (rA) binding”,Nucl. Acids Res., 15:6625-6641 (1987).
Gilchrest et al., “The Pathogenesis of Melanoma Induced by Ultravioled Radiation”,New England J. Med., 340:1341-1348 (1999).
Helmbach et al., “Drug-Resistance in Human Melanom”,In″nt. J. Cancer, 93:617-622 (2001).
van der Krol et al., “Modulation of Eukaryotic Gene Expression by Complementary RNA or DNA Sequences”,BioTechniques6:958-976 (1988).
Kromberg et al., “Albinism and Skin Cancer in Southern Africa”,Clin. Genet., 36:43-52 (1989).
Lee, S-T et al. “Organization and Sequence of the Human P Gene and Identification of New Family of Transport Proteins”,Genomics. Academic Press, San Diego, 26(2):354-363 (1995).
Lemaitre et al., “Specific Antiviral Activity of a Poly(L-lysine)-conjugated Oligodeoxyribonucleotide Sequence Complementary to Vesicular Stomatitis Virus N Protein mRNA Initiation Site”,Proc. Natl. Acad. Sci. (USA) 84:648-652 (1987).
Letsinger et al., “Cholesteryl-conjugated Oligonucleotides: Synthesis, Properties, and Activity as Inhibitors of Replication of Human Immunodeficiency Virus in Cell Culture”,Proc. Natl. Acad. Sci. (USA) 86:6553-6556 (1989).
Manga et al., “ThePink-Eyed DilutionGene and the Molecular Pathogenesis of Tyrosinase-Positive Albinism (OCA2)”,J. Dermatol. 26:738-747 (1999).
Manga et al., “Inverse Correlation Between Pink-Eyed Dilution Protein Expression and Induction of Melanogenesis by Bafilomycin A1”,Pigment Cell Res. 14:362-367 (2001).
Nordlund et al., eds,The Pigmentary System: Phsiology and Pathophysiology, Oxford University, New York (1998) pp. 217-229.
Penninckx, “A Short Review on the Role of Glutathione in the Response of Yeasts to Nutritional, Environmental, and Oxidative Stresses”,Enzyme Microb. Technol., 26:737-742 (2000).
Puri, Neelu et al. “Abberrant pH of Melanosomes in Pink-Eyed Dilution (p) mutant melanocytes.”Journal of Investigative Dermatology, 115(4):607-613 (2000).
Rinchik et al., “A Gene for the Mouse Pink-Eyed dilution Locus and for Human Type II Oculocutaneous Albinism”,Nature. 361:72-76 (1993).
Scriver et al.The Matabolic and Molecular Basis of Inherited Disease. eds, McGraw-Hill Proffesional Publishing, New York, 8thEd. (2000); pp. 4353-4392.
Staleva, Liliana et al. “Pink-eyed Dilution Protein Modulates Arsenic Sensitivity and Intracellular Glutathione Metabolism.”Molecular Biology of the Cell., 13(12): 4206-4220.
Zon, “Oligonucleotide Analogues as Potential Chemotherapeutic Agents”,Pharm. Res.5:539-549 (1998).
Manga Prashiela
Orlow Seth J.
Staleva Liliana
Martin Paul
New York University
Weber Jon
Wilmer Cutler Pickering Hale & Dorr LLP
LandOfFree
Assay for melanogenesis does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Assay for melanogenesis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Assay for melanogenesis will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3944893