Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1991-02-08
1992-10-13
Kepplinger, Esther L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435962, 435975, 436518, 436530, 436174, 436175, 436808, 436810, 436811, 436825, 436800, 436829, G01N 33569
Patent
active
051550229
ABSTRACT:
Diagnosis of Lyme disease by immunoassay for anti-Borrelia burgdorferi antibodies in the serum of a patient includes adsorption of crossreactive antibodies in the serum with antigen of Acinetobacter calcoaceticus or Treponema phagedensis prior to binding of anti-Borrelia antibodies to Borrelia burgdorferi antigen absorbed onto a solid support. The preferred assay is a flow-through assay using a porous membrane as the support and a dye-loaded liposome conjugated to a goat antihuman antibody for detection. The invention includes a kit of materials for performing the assay.
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Gossett Liane F.
Mapes James P.
Naqui Ali
Becton Dickinson and Company
Bidwell Carol E.
Btown Richard E.
Fugit Donna R.
Kepplinger Esther L.
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