Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2008-04-15
2008-04-15
Carlson, Karen Cochrane (Department: 1656)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
Reexamination Certificate
active
10222345
ABSTRACT:
A prothrombin time reagent for determination of low molecular weight heparin in frsh whole blood and in anti-coagulant treated blood is provided. The reagent is composed of recombinant animal tissue factor, and a mixture of synthetic phospholipids, which mixture includes a phosphatidylalcohol. A formulation buffer which includes a sensitivity adjuster is used in formulating the reagent. The recombinant animal tissue factor includes rabbit brain. The synthetic phospholipids of the mixture include palmitoyloleoylphosphatidylcholine (POPC), palmitoyloleoyl-phosphatidylserine (POPS), and a phosphatidylalcohol. The phosphatidyl alcohol includes dioleoylphosphatidylethanol, dioleoylphosphatidylmethanol, dioleoylphosphatidylpropanol, dioleoylphosphatidylbutanol, and dioleoylphosphatidylinositol. The sensitivity adjuster included in the formulation buffer is γ-Cyclodextrin. The formulated reagent is air-dried and remains stable for at least 3 weeks at 37° C.
REFERENCES:
patent: 5314695 (1994-05-01), Brown
patent: 5625036 (1997-04-01), Hawkins et al.
patent: 5858724 (1999-01-01), Novy et al.
patent: 6100072 (2000-08-01), Brucato et al.
patent: 6183979 (2001-02-01), Lee et al.
patent: 6194394 (2001-02-01), Hawkins
patent: 6403381 (2002-06-01), Mann et al.
patent: 2003/0104508 (2003-06-01), Gempeler et al.
patent: WO 99/10746 (1999-03-01), None
Besselaar, Blood Coagulation and Fibrinolysis, 6, p. 239-244 (1995).
Nelsestuen, J. Biological Chemistry, 276, No. 43, p. 39825-39831 (2001).
Miletich,Prothrombin Time, Williams Hematology, Fifth Edition, 1995; L82-L84.
Miletich,Activated Partial Thromboplastin Time, Williams Hematology, Fifth Edition, 1995; L85-L86.
Schultz et al.,The Influence of Heparin on the Prothrombin Time, Pharmacotherapy, vol. 11, No. 4, 1991; 312-316.
Holmes et al.,Novel, Bedside, Tissue Factor—Dependent Clotting Assay Permits Improved Assessment of Combination Antithrombotic and Antiplatelet Therapy, Circulation, 2000; 2051-2057.
Lawson et al.,Cooperative Activation of Human Factor IX by the Human Extrinsie Pathway of Blood Coagulation, The Journal of Biological Chemistry, vol. 266, No. 17, 1991; 11317-11327.
Mize et al.,Rapidpoint™ Coag Enoxaparin Test: Clinical Results for a POC Method for Monitoring Lovenox®(Enoxaparin Sodium)in Patients Undergoing PCI, American Society of Hematology 43rdAnnual Meeting and Exposition, 2001; 193.
Mize et al.,Development of the Rapidpoint™ Coag Enoxaparin Test System to Monitor Lovenox®(Enoxaparin Sodium)in PCI Patients, American Society of Hematology 43rdAnnual Meeting and Exposition, 2001; 185.
Harenberg et al., Blood Coagulation and Fibrinolysis, 7:453-458 (1996).
LaDuca Frank M.
Lee Ted C. K.
McBride Amanda B.
Carlson Karen Cochrane
International Technidyne Corporation
Rooke Agnes B.
Synnestvedt & Lechner
LandOfFree
Assay for low molecular weight heparin does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Assay for low molecular weight heparin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Assay for low molecular weight heparin will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3936889