Assay for interferon epsilon

Details Assay for interferon epsilon Assay for interferon epsilon

1984-07-06

1987-06-23

Nucker, Christine M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 29, 4351723, 435811, 435948, 424 85, C12Q 170, A61K 3900

Patent

active

046752820

ABSTRACT:
Disclosed is an assay procedure for detecting and quantifying interferon epsilon, a new composition of matter having selective antiviral activity on epithelial cells. The assay comprises incubating a preparation believed to contain interferon epsilon with human keratinocyte cells and with human fibroblast cells followed by a virus challenge. The presence of interferon epsilon is indicated if the preparation has antiviral activity on the keratinocytes but no detectable activity on the fibroblasts. The titer of the preparation may be determined by serially diluting it, incubating the dilution with subcultures of keratinocytes, challenging the subcultures with a virus, observing the viability of cells in the cultures, and comparing the results with a standard.

REFERENCES:
patent: 3910824 (1975-08-01), Cartwright et al.
Chemical Abstracts, vol. 100, (1984): 21419s.

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