Assay for inhibitors of a 24 kD cytoplasmic protease which activ

Details Assay for inhibitors of a 24 kD cytoplasmic protease which activ Assay for inhibitors of a 24 kD cytoplasmic protease which activ

1997-03-26

1999-09-14

Weber, Jon P.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

435226, C12Q 137, C12N 964

Patent

active

059521899

ABSTRACT:
A method is disclosed for assaying for inhibitors of a 24 kDa cytoplasmic protease associated with apoptosis. The protease has a defined amino acid composition, activity against the elastase-like substrate MAAVP, and induces DNA fragmentation associated with apoptosis in isolated U937 cell target nuclei.

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