Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1992-11-12
1996-07-30
Walsh, Stephen G.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 691, 4352401, 43525411, 536 231, 530350, C12Q 102, C07K 14705, C12N 500
Patent
active
055410715
ABSTRACT:
The invention features purified nucleic acids encoding the mammalian gastrin/CCK-B receptor family. The invention also features a) the gastrin and CCK-B receptor polypeptides, b) a method of identifying antagonists to the gastrin or CCK-B receptors, and c) a parietal cell cDNA expression library.
REFERENCES:
patent: 4675285 (1987-06-01), Clark
patent: 4735941 (1988-04-01), Freidinger et al.
Hughes et al., PNAS, vol. 87, p. 6728, 1990.
Escobedo et al., 1988, Journal of Biological Chemistry, 263, 1482-1487.
Yu et al., 1990, Am. J. Physiol., 258, G86-G95.
Rudenko et al., "Characterization of brain gastrin cholecystokinin-binding proteins," Biosis Abstract No. 91058376 of article in Ukrainskii Biokhimicheskii Zhurnal (USSR), 62:26-30, 1990.
Park et al., "A new selective gastrin receptor antagonist: characterization via studies with isolated canine gastric parietal and d-cells," Abstract, Digestion 46:85-86, 1990.
Matozaki et al., "Characterization of cholecystokinin receptors in gastric chief cells . . . chief cells," Biosis Abstract No. 89499881 of article in Japanese Journal of Gastroenterology (Japan) 86:1424-1428, 1989.
Kopin et al., "Expression cloning and characterization of the canine parietal cell gastrin receptor," PNAS, USA, 89:3605-3609, 1992.
Pisegna et al., "Molecular cloning of the human brain and gastric cholecystokinin receptor: structure, functional . . . localization," Biochemical and Biophysical Research Communications 189:296-303, 1992.
Wank et al., "Purification, molecular cloning, and functional expression of the cholecystokinin receptor from rat pancreas," PNAS USA 89:3125-3129, 1992.
Stephen A. Wank et al., "Brain and gastrointestinal cholecystokinin receptor family: Structure and functional expression," Natl. Acad. Sci. USA, vol. 89, pp. 8691-8695, Sep. 1992.
Ira Gantz et al., "Molecular cloning of a gene encoding the histamine H2 receptor," Proc. Natl. Acad. Sci. USA vol. 88, pp. 429-433, Jan. 1991.
Dialog search, p. 1, Ira Gantz, "Molecular Cloning and Expression of the Gastric Receptor," Dialog file No. 265/266, Federal Research in Progress, I.D. No. 0001;78226;506, Jan. 1, 1991.
O'Hara et al., Society for Neuroscience Abstracts, vol. 16, Part 1, 1990.
Le T. Duong et al., "Purification and Characterization of the Rat Pancreatic Cholecystokinin Receptor," The Journal of Biological Chemistry, vol. 264, No. 30, pp. 17990-17996 Oct. 25, 1989.
J. Szecowka et al., "Purification of the pancreatic cholecystokinin receptor," Regulatory Peptides, vol. 24, pp. 215-224, Mar. 1989.
Yakabi et al., "Isolation and Purification of a 72KD Gastrin Receptor from Canine Gastric Parietal Cell Membranes," Gastroenterology, vol. 94, No. 5, p. A505, May 1988.
New England Medical Center Hospitals Inc.
Teng Sally P.
Walsh Stephen G.
LandOfFree
Assay for identifying antagonists of gastrin and CCK-B receptors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Assay for identifying antagonists of gastrin and CCK-B receptors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Assay for identifying antagonists of gastrin and CCK-B receptors will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1657720