Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1986-02-05
1989-02-07
Nucker, Christine M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
424 858, 436501, 436518, 436536, 436548, 436813, 530387, G01N 33577
Patent
active
048031690
ABSTRACT:
Methods are disclosed for detecting, staging and monitoring breast cancer. The methods involve determining the amount of certain antigens, designated W1 and W9, in serum via quantitative immunoassays using anti-W1 or anti-W9 monoclonal antibodies. The amount detected is compared with amounts of the antigen found in normal sera, sera from breast cancer patients of predetermined stage, or other samples of the patient's own serum, depending upon the purpose of the assay.
REFERENCES:
patent: 4522918 (1985-06-01), Schlom et al.
patent: 4753894 (1988-06-01), Frankel et al.
Frankel et al "Tissue Distribution of Breast Cancer-Associated Antigens Defined by Monoclonal Antibodies", J. Biol. Res. Mod. 4:273-286 1985.
Ceriani et al, PNAS (1982) 79:5420-5424.
Burchell, J. et al, Int J Cancer (1984) 34:763-768.
Hayes, D. F., J Clin Invest (1985) 75:1671-1678.
Roberto L. Ceriani et al. (1983) Somatic Cell Genetics, 9:415-427.
Brown Joseph P.
Frankel Arthur E.
Horn Diane
Linsley Peter S.
Ochs Vincent W.
Cetus Corporation
Nucker Christine M.
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