Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving transferase
Patent
1994-04-01
1995-07-11
Wityshyn, Michael G.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving transferase
435 14, 435193, 436 87, 436164, 436172, 436800, 436811, 530395, 530400, 530829, 530830, C12Q 148, C12Q 154, C12N 910, G01N 2164
Patent
active
054320593
ABSTRACT:
A method is provided for detecting carbohydrate-deficient glycoproteins in samples taken from subjects with metabolic disorders, such as alcohol abuse and subjects who display a syndrome of carrying abnormal levels of carbohydrate deficient glycoproteins. The method involves steps of reglycosylating with a fluorescent-conjugate deglycosylated glycoproteins in a sample of body fluid from a subject. A further step involves fluorometric detection of fluoresceinylated carbohydrates incorporated into truncated serum glycoproteins.
REFERENCES:
Ashwell et al. "Carbohydrate-Specific Receptors of the Liver" Ann Rev. Biochem. 51: 531-533 1982.
Stibler "Carbohydrate-Deficient Transferrin in Serum: A New Marker of Potentially Harmful Alcohol Consumption Reviewed" Clin Chem 37(12): 2029-2037 1991.
Stibler, et al. "Glycoprotein Glycosyltransferase Activites in Serum in Alcohol-Abusing Patients & Healty Controls" Scand. J. Clin Lab Invest. 51(1) 43-51 1991.
Anton et al. "Two Methods for Measuring Carbohydrate-Deficient Transferrin in Inpatient Alcoholics & Healthy Controls Compared" Clin Chem. 40(3) 364-368 Mar. 1994.
Bean Pamela
Terryberry Jeff W.
Brotman Harris F.
Degen Nancy J.
Specialty Laboratories, Inc.
Wityshyn Michael G.
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