Assay for free thyroid hormone

Details Assay for free thyroid hormone Assay for free thyroid hormone

1980-03-21

1983-07-05

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

436500, G01N 3356, G01N 3358, G01N 3360

Patent

active

043917950

ABSTRACT:
Sample containing free and bound thyroid hormone; in particular, thyroxine, is contacted with immobilized binder; in particular, supported on a solid support, to bind the free thyroxine. After separating the bound thyroxine from the immobilized binder having free thyroxine bound thereto, the immobilized binder is contacted with labeled thyroxine; in particular, radiolabeled thyroxine. Unbound labeled thyroxine is removed, and the amount of bound and/or unbound labeled thyroxine is measured, with the free thyroxine concentration in the sample being inversely proportional to the amount of labeled thyroxine bound to the immobilized binder.

REFERENCES:
patent: 4046870 (1977-09-01), Hertl et al.
patent: 4225574 (1980-09-01), Romelli et al.
patent: 4235865 (1980-11-01), Thoma
patent: 4252782 (1981-02-01), Bailey
patent: 4279885 (1981-07-01), Reese

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