Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1993-07-30
1995-05-30
Ceperley, Mary E.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
436545, 436822, 530363, 530367, 530380, 530385, 5303898, 530404, 530405, 549441, G01N 33573, C07K 1644, C07D31760
Patent
active
054200105
ABSTRACT:
N-substituted azetidinones are a class of inhibitors of human leukocytes elastase which are known to be useful in the treatment of a wide variety of antiinflammatory and antidegenerative diseases. In inhibiting elastase, the therapeutic agents are shown to form a characteristic stable complex with the enzyme. In the assay disclosed herein, the inhibitor-enzyme complex is advantageously hydrolyzed and specific product(s) of the hydrolysis are measured. The assays are useful in a clinical setting, for determining appropriate dosage and assessing the effectiveness of treatment.
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Finke Paul E.
Hagmann William K.
Hanlon William A.
Humes John L.
Knight Wilson B.
Ceperley Mary E.
Merck & Co. , Inc.
Panzer Curtis C.
Rose David L.
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