Assay for determining analyte using mercury release followed by

Details Assay for determining analyte using mercury release followed by Assay for determining analyte using mercury release followed by

1988-10-12

1992-04-28

Wax, Robert A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

435 6, 435 71, 435 75, 435 792, 435810, 436501, 204403, 536 27, 935 77, 935 78, C12Q 168, G01N 3353

Patent

active

051088894

ABSTRACT:
An assay employing a tracer comprising a ligand having a mercury label wherein mercury label is released from at least one of a bound or free tracer phase and interacts with a metal. Analyte is determined by a change in at least one property of the metal caused by such interaction. The invention also relates to a device for such an assay wherein mercury ions released from a free or bound tracer are caused to eventually amalgamate with a metal, and the presence and/or amount of analyte is determined by changes in the metal resulting from the eventual amalgamation which may be measured electrically or by other means. The invention also relates to novel assay instruments, novel lancets, assay sensors, assay sensor packets, instrumentation and combinations of assay components, and related methods.

REFERENCES:
patent: 3853467 (1974-12-01), Giaever
patent: 4092233 (1978-05-01), Clemens et al.
patent: 4313734 (1982-02-01), Leuvering
patent: 4344438 (1982-08-01), Schultz
Frere et al. (1988) New J. Chem., vol. 12, No. 8, pp. 773-782.
Hopman et al. (1986) Nuc. Acids Res., vol. 14, No 16, pp. 6471-6488.
"Affinity Sensor: A New Technique for Developing Implantable Sensors for Glucose and Other Metabolites", Diabetes Care, vol. 5, No 3, May-Jun., pp. 245-253.
Chemical Abstracts, vol. 107, No. 1, Jul. 6, 1987.

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