Assay for determinig TNF or IL-1 convertase activity

Details Assay for determinig TNF or IL-1 convertase activity Assay for determinig TNF or IL-1 convertase activity

1995-02-08

1996-08-13

Fleisher, Mindy

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

435 74, 435 78, 435 23, 435219, 435963, 530324, 530326, 530332, C12Q 137, C07K 702, C07K 1481

Patent

active

055455182

ABSTRACT:
Compositions and methods are described for identifying inhibitors of mature protein hormone formation from a prohormone, and prophylactic and therapeutic uses of the inhibitors for treating diseases associated with elevated levels of the mature hormones, particulary sepsis, and autoimmune diseases.

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patent: 4766069 (1988-08-01), Aaron et al.
patent: 4892813 (1990-01-01), Cohen et al.
patent: 4897444 (1990-01-01), Brynes et al.
patent: 4923802 (1990-05-01), Gallis
patent: 5422425 (1995-06-01), Kriegler et al.
Cseh et al. "Alternative Cleavage of the Cachetin/TNF Propeptide Results in a Larger Inactive form of Serented Proten" JBC 1989 264 16256-16260.

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