Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-04-10
1999-12-07
Fredman, Jeffrey
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 4052, 435 405, 536 2431, C12Q 168, C12Q 108, C07H 2104
Patent
active
059981393
ABSTRACT:
The activation of neurons in specific areas of a mammalian brain are determined by measurement of levels of mRNA following administration of an agent that potentially affects neuronal activity. Differential levels of mRNA caused by an agent can be measured, as can the specific distribution of the alteration of neuronal activity. Many mental disorders are associated with the abnormal function of a particular area of the brain. The present invention allows the determination of which area of the brain, if any, is affected by an administered agent. Accordingly, the invention provides a valuable tool for assaying compounds as potential therapeutic agents.
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Gall Christine M.
Granger Richard
Lynch Gary
Palmer Linda C.
Bozicevic Karl
DeVore Dianna L.
Fredman Jeffrey
The Regents of the University of California
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