Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-02-21
1998-12-08
Housel, James C.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 74, C12P 2106
Patent
active
058467718
ABSTRACT:
Recombinant asparaginyl tRNA synthetase from human filarial parasite Brugia malayi. The enzyme is used in an assay for inhibitors of the synthetase and can be used as an antigen for producing antibody inhibitors of the disease, either monoclonal or polyclonal. The antibodies can be used to detect the synthetase and related enzymes. In particular, the synthetase can be used to produce an antibody to be used for detecting filarial nematodes. The synthetase can be used to produce adenylated nucleosides.
REFERENCES:
patent: 5561054 (1996-10-01), Kron et al.
Chandrashekar, R., et al., Mol. Biochem. Parasitology, vol. 64(2), 261-271 (Apr. 1994).
Dissanayake, S., et al., Am. J. Trop. Med. Hyg. 50(6), 727-734 (Jun. 1994).
Dissanayake, S., et al., Molecular and Biochemical Parasitology 56, 259-268 (1992).
Dissanayake, S., et al., Molecular and Biochemical Parasitology 56, 269-278 (1992).
Philipp, M., et al., Ann Rev. Microbiol. 42 685-716 (1988).
Carter, T. W., Ann. Rev. Biochem. 62 715-748 (1993).
EMBL Annual Report, 239-240 (1994).
Eriani, G., et al., Nature 347 203-206 (1990).
Cusack, S., et al., Nature 347 249-255 (1990).
Nilson, T. W., et al., Proc. Natl. Acad. Sci. USA 85 3604-3607 (1988).
Kron, M., et al., Mol. Biochem. Parasit. 52 289-292 (1992).
Cusack, S., et al., Nucleic Acids Research 19 3489-3497 (1991).
Targoff, I., et al., J. Clin. Invest. 91 2556-2564 (1993).
Love, L. A., et al., Medicine 70 360-374 (1991).
Bunn, C. C., et al., J. Exp. Med. 163 1281-1291 (1986).
Anselme, J., et al., Gene 84 481-485 (1989).
Bolle, P-A., et al., Yeast 8 205-213 (1992).
Bochner, B.R., et al., Cell, 37 225-232 (1984).
Segal, E., et al., Exp. Cell. Res. 167 119-126 (1986).
Walter, R.D., Trop. Med. Parasitol. 37 95 (1986).
Biou, V., et al., Science 263 1404-1410 (1994).
Belrhali, H., et al., Science 263 1432-1436 (1994).
Cusack, S. et al, Nucleic Acid Research, vol. 19(13), pp. 3489-3498, 1991.
Kron, M. et al, FEBs Letters, vol. 374, pp. 122-124, 1995.
Nilsen, T. W. et al, Proc. Nat'l Acad Sci, USA vol. 85, pp. 3604-3607, May, 1988.
Kron Michael A.
Leberman Reuben
Board of Trustees operating Michigan State University
European Molecular Biology Laboratory
Housel James C.
McLeod Ian C.
Portner Ginny Allen
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