Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Peptides containing saccharide radicals – e.g. – bleomycins – etc.
Patent
1984-11-09
1988-02-16
Kight, John
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Peptides containing saccharide radicals, e.g., bleomycins, etc.
530395, 530829, C07C10352, C07G 700
Patent
active
047256699
ABSTRACT:
A first glycoprotein having a molecular weight of approximately 120,000 daltons in the H9/HTLV-III cell line, of which approximately 90,000 daltons is the unglycosylated moiety, is obtained from cells infected with human T-cell leukemia virus, type III. A second glycoprotein having a molecular weight of aproximately 160,000 daltons is also obtained from such cells, of which approximately 90,000 daltons is the unglycosylated moiety and is substantially identical to the unglycosylated moiety of the first glycoprotein.
The presence, in a biological specimen, of either of these glycoproteins or of the unglycosylated moiety is indicative of the presence of cells infected by human T-cell leukemia virus. An assay for the glycoprotein or its unglycosylated moiety is a useful diagnostic procedure for determining such infection in biological specimens.
REFERENCES:
patent: 4520113 (1985-05-01), Gallo et al.
patent: 4524027 (1985-06-01), Bohn
Robey et al, "Prospect for Prevention of Human Immunodeficiency Virus Infection: Purified 120-kDa Envelope Glycoprotein Induces Neutralizing Antibody", Proc Natl Acad Sci USA, vol. 83, pp. 7023-7027, Sep. 1986.
Allan et al, "Major Glycoprotein Antigens that Induce Antibodies in AIDS Patients are Encoded by HTLV-III", Science, vol. 228, 1091-1093, 1985.
Berin et al, "Virus Envelope Protein of HTLV-III Represents Major Target Antigen for Antibodies in AIDS Patients", Science, vol. 228, 1094-1096, 1985.
Potocnjak et al., Science, vol. 215, 1637-1639 (1982).
Schupbach et al., Science, vol. 224, 503-505 (1984).
Essex Myron E.
Lee Tun-Hou
Kight John
Nutter Nathan M.
President and Fellows of Harvard College
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