Assay for detecting infection by HTLV-III

Details Assay for detecting infection by HTLV-III Assay for detecting infection by HTLV-III

1994-05-17

1998-03-24

Woodward, Michael P.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435810, 435974, 530395, 530826, C12Q 170, G01N 33564, C07K 1416

Patent

active

057311420

ABSTRACT:
A first glycoprotein having a molecular weight of approximately 120,000 daltons in the H9/HTLV-III cell line, of which approximately 90,000 daltons is the unglycosylated moiety, is obtained from cells infected with human T-cell leukemia virus, type III. A second glycoprotein having a molecular weight of approximately 160,000 daltons is also obtained from such cells, of which approximately 90,000 daltons is the unglycosylated moiety and is substantially identical to the unglycosylated moiety of the first glycoprotein.
The presence, in a biological specimen, of either of these unglycosylated or of the unglycosylated moiety is indicative of the presence of cells infected by human T-cell leukemia virus. An assay for the glycoprotein or its unglycosylated moiety is a useful diagnostic procedure for determining such infection in biological specimens.

REFERENCES:
patent: 4520113 (1985-05-01), Gallo
patent: 4524027 (1985-06-01), Bohn
patent: 4708818 (1987-11-01), Montagnier et al.
patent: 4716102 (1987-12-01), Levy
Veronese et al., Science 229:1402-1405, 1985.
Popovic et al., Science 224:497-500, 1984.
Montagnier et al., Science 225:63-66, 1984.
Kalyanaraman et al., Science 225:321-323, 1984.
Gallo et al., Science 224:500-503, 1984.
AKZO Opposition to EP 0 201 588 and attachments (103 pages).
Eisenberg et al., Effect of Monoclonal Antibodies on Limited Proteolysis of Native Glycoprotein gD of Herpes Simplex Virus Type 1, J. Virology 41:478-488, 1982.
Matthews et al., Synthesis and Processing of Glycoprotein D of Herpes Simplex Virus Type 1 and 2 in an Vitro System, J. Virology 48:521-533, 1983.
Synder et al., The Feline Oncornavirus-Associated Cell Membrane Antigen (FOCMA) is Related to, but Distinguishable from, FeLV-C gp70, Virology 131:315-327, 1983.
Fletcher et al., Chromatographic Separation and Antigenic Analysis of Proteins of the Oncornaviruses Virology 64:358-366, 1975.
Tung et al., Relationships of gp70 of MyLV Envelopes to gp70 Components of Mouse Lymphocyte Plasma Membranes J. Exp. Med. 146:1280-1284, 1977.
Potocnjak et al., Science 215:1637-1639 (1982).
Sangaharan et al., Science 224:168-174 (1984).
Muesing et al., Nature 313:450-458 (1985).
Allan et al., Science 288:1091-1094 (1985).
Kitchen et al., Nature 312:367-369 (1984).
Cleveland et al., J. Biol. Chem. 252:1102-1106 (1977).
Snyder et al., Cold Spring Harbor Symposia on Quntitative Biology, vol. ILIV, pp. 787-799 (1980).
Morgan et al., J. Virology 46:177-186 (1983).
Robey et al., Proc. Nat'l Acad. Sci. (USA) 83:7023-7027 (1986).
Barin et al., Science 228:1094-1096 (1985).
Sangaharan et al., Science 224:506-508 (1984).
Schupbach et al., "Serological Analysis of a Subgroup of Human T-Retroviruses (HTLV-III) Associated with AIDS" Science 224:503-506 (1984).
Hahn et al., "Molecular cloning and characterization of the HTLV-III virus associated with with AIDS" Nature 312:166-169 (1984).
Ho et al., "HTLV-III in the Semen and Blood of a Healthy Homosexual Man" Science 226:451-453 (1984).
Safai et al., "Seroepidemiological Studies of Human T-Lymphotrophic Retrovirus Type III in Acquired Immunodeficiency Syndrome" Lancet, Jun. 30, 1984, 1438-1440.
Pan et al., J. Infect. Dis. 135:626-631 (1987).
Towbin et al., Proc. Nat'l Acad. Sci. USA 76:4350-4354 (1979).
Erickson et al., J. Immunol. Methods 51:241-249 (1982).
Chang-Meyer et al., Virol. 181:288-294 (1991).
McClure et al., Current Topics in AIDS, vol. 1, Ch. 5, pp. 95, 102-105.
Mortimer et al., Current Topics in AIDS, vol. 1, Ch. 7, pp. 133, 140-141, 150-151.
Eisenberg et al., J. Virol. 41:478-488 (1982).
Matthews et al., J. Virol. 48:521-523 (1983).
Snyder et al., Virology 131:315-327 (1983).
Fletcher et al., Virology 64:358-366 (1975).
Tung et al., J. Exp. Med. pp. 1280-1284 (1978).
Sodroski et al., Science 22:421-424 (1984).
Lee et al., Proc. Natl. Acad. Sci. USA 81:3856-3860 (1984).
Robey et al., Proc. Nat'l. Acad. Sci. (USA) (1986) 83:7023-7027.
Barin et al., Science (1985) 228:1094-1096.
Sarngadharan et al., Science (1984) 224:506-508.
Pan et al., J. Infect. Dis. (1987) 135:626-631.
Towbin et al., Proc. Nat'l. Acad. Sci. USA (1979) 76:4350-4354.
Erickson et al., J. Immunol. Methods (1982) 51:241-249.
Schupbach et al, "Serological Analysis of a Subgroup of Human T-Retroviruses (HTLV-III) Associated with AIDS" Science, 224(1984) 503-506.
Hahn et al, "Molecular cloning and characterization of the HTLV-III Virus associated with AIDS" Nature, 312(1984) 166-169.
Ho et al, "HTLV-III in the Seman and Blood of a Healthy Homosexual Man" Science, 226 (1984) 451-453.
Safai et al, "Seroepidemiological Studies of Human T-Lymphotropic Retrovirus type III in Acquired Immunodeficiency Syndrome" Lancet, Jun. 30, 1984 1438-1440.
Kitchen et al, "Aetiology of AIDS-antibodies to human T-Cell Leukaemia Virus (type III) in haemophiliacs" Nature 312(1984)367-9.

Affiliated with

Also associated with

Rating

Assay for detecting infection by HTLV-III does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Assay for detecting infection by HTLV-III, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Assay for detecting infection by HTLV-III will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2287826