Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Reexamination Certificate
2008-03-25
2008-03-25
Lankford, Jr., Leon B (Department: 1651)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
C435S025000, C435S026000, C435S028000, C435S317100
Reexamination Certificate
active
10925913
ABSTRACT:
An assay for assessing the permeability of mitochondrial membranes is provided. The assay is based on enzymatic reactions that produce a detectable signal in the presence of intra-mitochondrial compounds. In some embodiments, the intra-mitochondrial compounds may be reduced and/or oxidized nicotinamide adenine dinucleotides (i.e., NADH and NAD+, respectively). The assay may optionally be provided in the form of a kit, and may further be useful in the discovery and interrogation of compounds that may serve to inhibit pathologic increase in mitochondrial membrane permeability, which is associated with numerous and varied mammalian disease.
REFERENCES:
Kristian, Tibor, et al.; “A Fluorescence-Based Technique for Screening Compounds That Protect Against Damage to Brain Mitochondria”; Brain Research Protocols, vol. 13, pp. 176-182, 2004.
Fiskum Gary
Kristian Tibor
Foley & Lardner LLP
Ford Allison M.
Lankford, Jr. Leon B
Rutherford Victoria S.
University of Maryland
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